Ceritinib in ALK-rearranged non-small-cell lung cancer

Non-small-cell lung cancer (NSCLC) harboring the anaplastic lymphoma kinase gene (ALK) rearrangement is sensitive to the ALK inhibitor crizotinib, but resistance invariably develops. Ceritinib (LDK378) is a new ALK inhibitor that has shown greater antitumor potency than crizotinib in preclinical stu...

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Main Authors:	Shaw, Alice T. (Author) , Kim, Dong-Wan (Author) , Mehra, Ranee (Author) , Tan, Daniel S. W. (Author) , Felip, Enriqueta (Author) , Chow, Laura Q. M. (Author) , Camidge, D. Ross (Author) , Vansteenkiste, Johan (Author) , Sharma, Sunil (Author) , De Pas, Tommaso (Author) , Riely, Gregory J. (Author) , Solomon, Benjamin J. (Author) , Wolf, Juergen (Author) , Thomas, Michael (Author) , Schuler, Martin (Author) , Liu, Geoffrey (Author) , Santoro, Armando (Author) , Lau, Yvonne Y. (Author) , Goldwasser, Meredith (Author) , Boral, Anthony L. (Author) , Engelman, Jeffrey A. (Author)
Format:	Article (Journal)
Language:	English
Published:	2014 March 27
In:	The New England journal of medicine Year: 2014, Volume: 370, Issue: 13, Pages: 1189-1197
ISSN:	1533-4406
DOI:	10.1056/NEJMoa1311107
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa1311107 Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/10.1056/NEJMoa1311107
Author Notes:	Alice T. Shaw, Dong-Wan Kim, Ranee Mehra, Daniel S.W. Tan, Enriqueta Felip, Laura Q.M. Chow, D. Ross Camidge, Johan Vansteenkiste, Sunil Sharma, Tommaso De Pas, Gregory J. Riely, Benjamin J. Solomon, Juergen Wolf, Michael Thomas, Martin Schuler, Geoffrey Liu, Armando Santoro, Yvonne Y. Lau, Meredith Goldwasser, Anthony L. Boral, Jeffrey A. Engelman