Clinically actionable strategies for studying neural influences in cancer

Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the stra...

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Main Authors: Demir, Ihsan Ekin (Author) , Reyes, Carmen Mota (Author) , Alrawashdeh, Wasfi (Author) , Ceyhan, Güralp O. (Author) , Deborde, Sylvie (Author) , Friess, Helmut (Author) , Görgülü, Kivanc (Author) , Istvanffy, Rouzanna (Author) , Jungwirth, David (Author) , Kuner, Rohini (Author) , Maryanovich, Maria (Author) , Na’ara, Shorook (Author) , Renders, Simon (Author) , Saloman, Jami L. (Author) , Scheff, Nicole N. (Author) , Steenfadt, Hendrik (Author) , Stupakov, Pavel (Author) , Thiel, Vera (Author) , Verma, Divij (Author) , Yilmaz, Bengi Su (Author) , White, Ruth A. (Author) , Wang, Timothy C. (Author) , Wong, Richard J. (Author) , Frenette, Paul S. (Author) , Gil, Ziv (Author) , Davis, Brian M. (Author)
Format: Article (Journal)
Language:English
Published: 11 June 2020
In: Cancer cell
Year: 2020, Volume: 38, Issue: 1, Pages: 11-14
ISSN:1878-3686
DOI:10.1016/j.ccell.2020.05.023
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccell.2020.05.023
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1535610820302737
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Author Notes:Ihsan Ekin Demir, Carmen Mota Reyes, Wasfi Alrawashdeh, Güralp O. Ceyhan, Sylvie Deborde, Helmut Friess, Kivanc Görgülü, Rouzanna Istvanffy, David Jungwirth, Rohini Kuner, Maria Maryanovich, Shorook Na’ara, Simon Renders, Jami L. Saloman, Nicole N. Scheff, Hendrik Steenfadt, Pavel Stupakov, Vera Thiel, Divij Verma, Bengi Su Yilmaz, Ruth A. White, Timothy C. Wang, Richard J. Wong, Paul S. Frenette, Ziv Gil, and Brian M. Davis
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Summary:Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating these findings from bench to the clinic.
Item Description:Gesehen am 08.09.2020
Physical Description:Online Resource
ISSN:1878-3686
DOI:10.1016/j.ccell.2020.05.023