Cover Image

The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas

The transcription factor OCT4 is an established diagnostic marker for central nervous system (CNS) germinoma. However, no data are available to date concerning the expression of its downstream target undifferentiated embryonic cell transcription factor 1 (UTF1) in CNS germ cell tumours. We examined...

Full description

Saved in:
Bibliographic Details
Main Authors: Pantazis, Georgios (Author) , Harter, Patrick N. (Author) , Capper, David (Author) , Kohlhof, Patricia (Author) , Mittelbronn, Michel (Author) , Schittenhelm, Jens (Author)
Format: Article (Journal)
Language:English
Published: 23 February 2016
In: Pathology
Year: 2014, Volume: 46, Issue: 3, Pages: 225-229
ISSN:1465-3931
DOI:10.1097/PAT.0000000000000071
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/PAT.0000000000000071
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0031302516306080
Get full text
Author Notes:Georgios Pantazis, Patrick N. Harter, David Capper, Patricia Kohlhof, Michel Mittelbronn and Jens Schittenhelm
Description
Summary:The transcription factor OCT4 is an established diagnostic marker for central nervous system (CNS) germinoma. However, no data are available to date concerning the expression of its downstream target undifferentiated embryonic cell transcription factor 1 (UTF1) in CNS germ cell tumours. We examined 21 CNS germinomas and two mixed CNS germ cell tumours for UTF1 and the post-transcriptional regulator LIN28 immunohistochemical expression. We compared the profile to established diagnostic germinoma markers and to the expression in six testicular and four metastatic germ cell tumours as well as 150 CNS tumours of various backgrounds.
Item Description:Available online 23 February 2016
Gesehen am 09.09.2020
Physical Description:Online Resource
ISSN:1465-3931
DOI:10.1097/PAT.0000000000000071

Similar Items