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Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma

Previous studies demonstrated the relevance of focal lesions (FL) in whole-body magnetic resonance imaging (wb-MRI) at the initial workup of patients with smoldering multiple myeloma (SMM). The aim of this study was to assess the effects of longitudinal wb-MRIs on progression into multiple myeloma (...

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Main Authors: Merz, Maximilian (Author) , Hielscher, Thomas (Author) , Wagner-Gund, Barbara (Author) , Sauer, Sandra (Author) , Shah, Sofia (Author) , Raab, Marc-Steffen (Author) , Jauch, Anna (Author) , Neben, Kai (Author) , Hose, Dirk (Author) , Egerer, Gerlinde (Author) , Weber, Marc-André (Author) , Delorme, Stefan (Author) , Goldschmidt, Hartmut (Author) , Hillengaß, Jens (Author)
Format: Article (Journal)
Language:English
Published: [2014]
In: Leukemia
Year: 2014, Volume: 28, Issue: 9, Pages: 1902-1908
ISSN:1476-5551
DOI:10.1038/leu.2014.75
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/leu.2014.75
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/leu201475
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Author Notes:M. Merz, T. Hielscher, B. Wagner, S. Sauer, S. Shah, M. S. Raab, A. Jauch, K. Neben, D. Hose, G. Egerer, M.-A. Weber, S. Delorme, H. Goldschmidt, J. Hillengass
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Summary:Previous studies demonstrated the relevance of focal lesions (FL) in whole-body magnetic resonance imaging (wb-MRI) at the initial workup of patients with smoldering multiple myeloma (SMM). The aim of this study was to assess the effects of longitudinal wb-MRIs on progression into multiple myeloma (MM). Sixty-three patients with SMM were analyzed who received at least two wb-MRIs for follow-up before progression into MM. Radiological progressive disease (MRI-PD) was defined as detection of new FL or increase in diameter of existing FL and a novel or progressive diffuse infiltration. Radiological stable disease (MRI-SD) was defined by no change compared with the prior MRI. Patients were followed-up every 3-6 months, including a serological and clinical evaluation. One Hundred and eighty-two wb-MRIs were analyzed. MRI-PD occurred in 31 patients (49%), and 25 (40%) patients developed MM. MRI-PD was highly significantly associated with progression into MM, regardless of findings at the initial MRI. In multivariate analysis, MRI-PD remained a risk factor, independent of relevant baseline parameters like serum monoclonal protein or ⩾95% aberrant plasma cells in the bone marrow. Patients with MRI-SD had no higher risk of progression, even when FL were present at the initial MRI. Therefore, MRI is suitable for the follow-up of patients with SMM.
Item Description:Advance online publication: 14 March 2014
Gesehen am 10.09.2020
Physical Description:Online Resource
ISSN:1476-5551
DOI:10.1038/leu.2014.75

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