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Infiltrative patterns of glioblastoma: identification of tumor progress using apparent diffusion coefficient histograms

Purpose To investigate whether apparent diffusion coefficient (ADC) histogram analysis can differentiate between patients presenting T2-progress and patients presenting stable T2-signal in glioblastoma. Materials and Methods Fourteen patients presenting an isolated T2-progress and a matched control...

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Main Authors: Lutz, Kira (Author) , Wiestler, Benedikt (Author) , Graf, Markus (Author) , Bäumer, Philipp (Author) , Floca, Ralf (Author) , Schlemmer, Heinz-Peter (Author) , Heiland, Sabine (Author) , Wick, Wolfgang (Author) , Bendszus, Martin (Author) , Radbruch, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 2014
In: Journal of magnetic resonance imaging
Year: 2013, Volume: 39, Issue: 5, Pages: 1096-1103
ISSN:1522-2586
DOI:10.1002/jmri.24258
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/jmri.24258
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.24258
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Author Notes:Kira Lutz MD, Benedikt Wiestler MD, Markus Graf MSc, Philipp Bäumer MD, Ralf Floca PhD, Heinz-Peter Schlemmer MD, PhD, Sabine Heiland PhD, Wolfgang Wick MD, Martin Bendszus MD, and Alexander Radbruch MD, JD
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Summary:Purpose To investigate whether apparent diffusion coefficient (ADC) histogram analysis can differentiate between patients presenting T2-progress and patients presenting stable T2-signal in glioblastoma. Materials and Methods Fourteen patients presenting an isolated T2-progress and a matched control group exhibiting stable disease were included. Relative ADC value distribution within tumoral and peritumoral FLAIR hyperintensities were evaluated using ADC-histogram analysis. Severity and frequency of ADC shift between baseline, T2-progress, and subsequent T1-progress were analyzed using the Wilcoxon test. Results The shift of ADC histograms either to higher or to lower values in case of T2-progress was significantly more severe than in the control group (P value 0.05). Furthermore, a significant shift toward lower ADC values (P value 0.02) was detected when comparing ADC histograms of patients with T2-progress and subsequent T1-progress. Conclusion The basis for the observed ADC shift in isolated T2-progress may be time dependent: Initially, formation of peritumoral edema may cause an increase of ADC values that is followed by tumor cells infiltrating the surrounding tissue, causing a subsequent decrease of ADC values. The shift toward lower ADC values in case of subsequent T1-progress confirms this hypothesis and provides further evidence for T2-progress being an intermediate step between stable disease (SD) and T1-progress. J. Magn. Reson. Imaging 2014;39:1096-1103. © 2013 Wiley Periodicals, Inc.
Item Description:Gesehen am 15.09.2020
First published: 30 September 2013
Physical Description:Online Resource
ISSN:1522-2586
DOI:10.1002/jmri.24258

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