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Inherited genetic susceptibility to multiple myeloma

Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs)...

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Main Authors: Morgan, Gareth (Author) , Johnson, David C. (Author) , Weinhold, Niels (Author) , Goldschmidt, Hartmut (Author) , Landgren, O. (Author) , Lynch, H. T. (Author) , Hemminki, Kari (Author) , Houlston, R. S. (Author)
Format: Article (Journal)
Language:English
Published: 2014
In: Leukemia
Year: 2013, Volume: 28, Issue: 3, Pages: 518-524
ISSN:1476-5551
DOI:10.1038/leu.2013.344
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/leu.2013.344
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/leu2013344
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Author Notes:G.J. Morgan, D.C. Johnson, N. Weinhold, H. Goldschmidt, O. Landgren, H.T. Lynch, K. Hemminki, and R.S. Houlston

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520 |a Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility. 
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