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The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency

Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be lifesaving for the affected patients and also provide a unique opportunity to study the effect of specific genes on human immune function. In t...

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Main Authors: Turvey, Stuart E. (Author) , Durandy, Anne (Author) , Fischer, Alain (Author) , Fung, Shan-Yu (Author) , Geha, Raif S. (Author) , Gewies, Andreas (Author) , Giese, Thomas (Author) , Greil, Johann (Author) , Keller, Bärbel (Author) , McKinnon, Margaret L. (Author) , Neven, Bénédicte (Author) , Rozmus, Jacob (Author) , Ruland, Jürgen (Author) , Snow, Andrew L. (Author) , Stepensky, Polina (Author) , Warnatz, Klaus (Author)
Format: Article (Journal)
Language:English
Published: 31 July 2014
In: The journal of allergy and clinical immunology
Year: 2014, Volume: 134, Issue: 2, Pages: 276-284
ISSN:1097-6825
DOI:10.1016/j.jaci.2014.06.015
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jaci.2014.06.015
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0091674914008653
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Author Notes:Stuart E. Turvey, BBS, DPhil, FRCPC, Anne Durandy, MD, PhD, Alain Fischer, MD, PhD, Shan-Yu Fung, PhD, Raif S. Geha, MD, Andreas Gewies, PhD, Thomas Giese, MD, Johann Greil, MD, Bärbel Keller, MSc, Margaret L. McKinnon, MD, Bénédicte Neven, MD, Jacob Rozmus, MD, Jürgen Ruland, MD, Andrew L. Snow, PhD, Polina Stepensky, MD, and Klaus Warnatz, MD
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Summary:Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be lifesaving for the affected patients and also provide a unique opportunity to study the effect of specific genes on human immune function. In the past 18 months, a number of independent groups have begun to define novel PIDs caused by defects in the caspase recruitment domain family, member 11 (CARD11)-B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10)-mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1 [CBM]) signalosome complex. The CBM complex forms an essential molecular link between the triggering of cell-surface antigen receptors and nuclear factor κB activation. Germline mutations affecting the CBM complex are now recognized as the cause of novel combined immunodeficiency phenotypes, which all share abnormal nuclear factor κB activation and dysregulated B-cell development as defining features. For this “Current perspectives” article, we have engaged experts in both basic biology and clinical immunology to capture the worldwide experience in recognizing and managing patients with PIDs caused by CBM complex mutations.
Item Description:Gesehen am 16.09.2020
Physical Description:Online Resource
ISSN:1097-6825
DOI:10.1016/j.jaci.2014.06.015

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