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Whole brain radiotherapy (WBRT) for leptomeningeal metastasis from NSCLC in the era of targeted therapy: a retrospective study

Leptomeningeal metastasis (LM) is a rare but detrimental complication in patients with non-small cell lung cancer (NSCLC). Although whole brain radiotherapy (WBRT) is used to eliminating cancer cells or microscopic foci, it is becoming less favorable due to the concerns over neurocognitive toxicity....

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Main Authors: Zhen, Junjie (Author) , Wen, Lei (Author) , Lai, Mingyao (Author) , Zhou, Zhaoming (Author) , Shan, Changguo (Author) , Li, Shaoqun (Author) , Lin, Tao (Author) , Wu, Jie (Author) , Wang, Wensheng (Author) , Xu, Shaoqiang (Author) , Liu, Da (Author) , Lu, Ming (Author) , Zhu, Dan (Author) , Chen, Longhua (Author) , Cai, Linbo (Author) , Zhou, Cheng (Author)
Format: Article (Journal)
Language:English
Published: 31 July 2020
In: Radiation oncology
Year: 2020, Volume: 15
ISSN:1748-717X
DOI:10.1186/s13014-020-01627-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13014-020-01627-y
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Author Notes:Junjie Zhen, Lei Wen, Mingyao Lai, Zhaoming Zhou, Changguo Shan, Shaoqun Li, Tao Lin, Jie Wu, Wensheng Wang, Shaoqiang Xu, Da Liu, Ming Lu, Dan Zhu, Longhua Chen, Linbo Cai and Cheng Zhou
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Summary:Leptomeningeal metastasis (LM) is a rare but detrimental complication in patients with non-small cell lung cancer (NSCLC). Although whole brain radiotherapy (WBRT) is used to eliminating cancer cells or microscopic foci, it is becoming less favorable due to the concerns over neurocognitive toxicity. This study aimed to re-evaluate the role of WBRT in the setting of modern targeted therapy.
Item Description:Gesehen am 17.09.2020
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-020-01627-y

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