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Inhibition of IGF-I-related intracellular signaling pathways by proinflammatory cytokines in growth plate chondrocytes

Children with chronic inflammatory diseases suffer from severe growth failure associated with resistance toward the anabolic action of insulin-like growth factor I (IGF-I). We hypothesized that proinflammatory cytokines interfere with IGF-I signaling.

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Bibliographic Details
Main Authors: Choukair, Daniela (Author) , Hügel, Ulrike (Author) , Sander, Anja (Author) , Uhlmann, Lorenz (Author) , Tönshoff, Burkhard (Author)
Format: Article (Journal)
Language:English
Published: [September 2014]
In: Pediatric research
Year: 2014, Volume: 76, Issue: 3, Pages: 245-251
ISSN:1530-0447
DOI:10.1038/pr.2014.84
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/pr.2014.84
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/pr201484
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Author Notes:Daniela Choukair, Ulrike Hügel, Anja Sander, Lorenz Uhlmann and Burkhard Tönshoff
Description
Summary:Children with chronic inflammatory diseases suffer from severe growth failure associated with resistance toward the anabolic action of insulin-like growth factor I (IGF-I). We hypothesized that proinflammatory cytokines interfere with IGF-I signaling.
Item Description:Avance online publication 16 July 2014
Gesehen am 18.09.2020
Physical Description:Online Resource
ISSN:1530-0447
DOI:10.1038/pr.2014.84

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