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Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells

Nuclear factor of activated T‐cells 5 (NFAT5) has recently been described to control the phenotype of vascular smooth muscle cells (VSMCs). Although an increase in wall stress or stretch (eg, elicited by hypertension) is a prototypic determinant of VSMC activation, the impact of this biomechanical f...

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Bibliographic Details
Main Authors: Scherer, Clemens Martin (Author) , Pfisterer, Larissa (Author) , Wagner, Andreas H. (Author) , Zappe, Maren (Author) , Cattaruzza, Marco (Author) , Hecker, Markus (Author) , Korff, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 10 Mar 2014
In: Journal of the American Heart Association
Year: 2014, Volume: 3, Issue: 2
ISSN:2047-9980
DOI:10.1161/JAHA.113.000626
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/JAHA.113.000626
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/JAHA.113.000626
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Author Notes:Clemens Scherer, Larissa Pfisterer, Andreas H. Wagner, Maren Hödebeck, Marco Cattaruzza, Markus Hecker Markus, Thomas Korff
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Summary:Nuclear factor of activated T‐cells 5 (NFAT5) has recently been described to control the phenotype of vascular smooth muscle cells (VSMCs). Although an increase in wall stress or stretch (eg, elicited by hypertension) is a prototypic determinant of VSMC activation, the impact of this biomechanical force on the activity of NFAT5 is unknown. This study intended to reveal the function of NFAT5 and to explore potential signal transduction pathways leading to its activation in stretch‐stimulated VSMCs.
Item Description:Gesehen am 22.09.2020
Physical Description:Online Resource
ISSN:2047-9980
DOI:10.1161/JAHA.113.000626

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