Buchumschlag

Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells

Nuclear factor of activated T‐cells 5 (NFAT5) has recently been described to control the phenotype of vascular smooth muscle cells (VSMCs). Although an increase in wall stress or stretch (eg, elicited by hypertension) is a prototypic determinant of VSMC activation, the impact of this biomechanical f...

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Bibliographische Detailangaben
Hauptverfasser: Scherer, Clemens Martin (VerfasserIn) , Pfisterer, Larissa (VerfasserIn) , Wagner, Andreas H. (VerfasserIn) , Zappe, Maren (VerfasserIn) , Cattaruzza, Marco (VerfasserIn) , Hecker, Markus (VerfasserIn) , Korff, Thomas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 Mar 2014
In: Journal of the American Heart Association
Year: 2014, Jahrgang: 3, Heft: 2
ISSN:2047-9980
DOI:10.1161/JAHA.113.000626
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/JAHA.113.000626
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/JAHA.113.000626
Volltext
Verfasserangaben:Clemens Scherer, Larissa Pfisterer, Andreas H. Wagner, Maren Hödebeck, Marco Cattaruzza, Markus Hecker Markus, Thomas Korff
Beschreibung
Zusammenfassung:Nuclear factor of activated T‐cells 5 (NFAT5) has recently been described to control the phenotype of vascular smooth muscle cells (VSMCs). Although an increase in wall stress or stretch (eg, elicited by hypertension) is a prototypic determinant of VSMC activation, the impact of this biomechanical force on the activity of NFAT5 is unknown. This study intended to reveal the function of NFAT5 and to explore potential signal transduction pathways leading to its activation in stretch‐stimulated VSMCs.
Beschreibung:Gesehen am 22.09.2020
Beschreibung:Online Resource
ISSN:2047-9980
DOI:10.1161/JAHA.113.000626

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