Copertina

Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7

Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply f...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Heinonen, Ann-Marie (Autore) , Rahman, Mahbubur (Autore) , Dogbevia, Godwin (Autore) , Jakobi, Hannah (Autore) , Wölfl, Stefan (Autore) , Sprengel, Rolf (Autore) , Schwaninger, Markus (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 11 March 2014
In: BMC neuroscience
Year: 2014, Volume: 15, Fascicolo: 1
ISSN:1471-2202
DOI:10.1186/1471-2202-15-38
Accesso online:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2202-15-38
Verlag, lizenzpflichtig, Volltext: https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-15-38
Testo
Note sull'autore:Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel and Markus Schwaninger
Descrizione
Riassunto:Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, BMP2 and the BMP inhibitor Noggin under the control of rAAV vectors in vivo. For visual control of rAAV-mediated BMP (v-BMP) expression we fused the secreted morphogenic polypeptides and the fluorescent reporter protein Venus via the ‘ribosomal skip’ promoting 2A peptide-bridge.
Descrizione del documento:Gesehen am 22.09.2020
Descrizione fisica:Online Resource
ISSN:1471-2202
DOI:10.1186/1471-2202-15-38

Documenti analoghi