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Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7

Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply f...

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Bibliographic Details
Main Authors: Heinonen, Ann-Marie (Author) , Rahman, Mahbubur (Author) , Dogbevia, Godwin (Author) , Jakobi, Hannah (Author) , Wölfl, Stefan (Author) , Sprengel, Rolf (Author) , Schwaninger, Markus (Author)
Format: Article (Journal)
Language:English
Published: 11 March 2014
In: BMC neuroscience
Year: 2014, Volume: 15, Issue: 1
ISSN:1471-2202
DOI:10.1186/1471-2202-15-38
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2202-15-38
Verlag, lizenzpflichtig, Volltext: https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-15-38
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Author Notes:Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel and Markus Schwaninger
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Summary:Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, BMP2 and the BMP inhibitor Noggin under the control of rAAV vectors in vivo. For visual control of rAAV-mediated BMP (v-BMP) expression we fused the secreted morphogenic polypeptides and the fluorescent reporter protein Venus via the ‘ribosomal skip’ promoting 2A peptide-bridge.
Item Description:Gesehen am 22.09.2020
Physical Description:Online Resource
ISSN:1471-2202
DOI:10.1186/1471-2202-15-38

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