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Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7

Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply f...

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Hauptverfasser: Heinonen, Ann-Marie (VerfasserIn) , Rahman, Mahbubur (VerfasserIn) , Dogbevia, Godwin (VerfasserIn) , Jakobi, Hannah (VerfasserIn) , Wölfl, Stefan (VerfasserIn) , Sprengel, Rolf (VerfasserIn) , Schwaninger, Markus (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 11 March 2014
In: BMC neuroscience
Year: 2014, Jahrgang: 15, Heft: 1
ISSN:1471-2202
DOI:10.1186/1471-2202-15-38
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2202-15-38
Verlag, lizenzpflichtig, Volltext: https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-15-38
Volltext
Verfasserangaben:Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel and Markus Schwaninger
Beschreibung
Zusammenfassung:Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, BMP2 and the BMP inhibitor Noggin under the control of rAAV vectors in vivo. For visual control of rAAV-mediated BMP (v-BMP) expression we fused the secreted morphogenic polypeptides and the fluorescent reporter protein Venus via the ‘ribosomal skip’ promoting 2A peptide-bridge.
Beschreibung:Gesehen am 22.09.2020
Beschreibung:Online Resource
ISSN:1471-2202
DOI:10.1186/1471-2202-15-38

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