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The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at cod...

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Main Authors: Ballhausen, Alexej (Author) , Przybilla, Moritz Jakob (Author) , Jendrusch, Michael (Author) , Haupt, Saskia (Author) , Schygulla, Elisabeth (Author) , Seidler, Florian (Author) , Witt, Johannes (Author) , Hernandez Sanchez, Alejandro (Author) , Urban, Katharina (Author) , Draxlbauer, Markus (Author) , Krausert, Sonja (Author) , Ahadova, Aysel (Author) , Kalteis, Martin Simon (Author) , Pfuderer, Pauline Luise (Author) , Heid, Daniel (Author) , Stichel, Damian (Author) , Gebert, Johannes (Author) , Bonsack, Maria (Author) , Schott, Sarah (Author) , Bläker, Hendrik (Author) , Seppälä, Toni (Author) , Mecklin, Jukka-Pekka (Author) , Ten Broeke, Sanne W. (Author) , Nielsen, Maartje (Author) , Heuveline, Vincent (Author) , Krzykalla, Julia (Author) , Benner, Axel (Author) , Riemer, Angelika (Author) , Knebel Doeberitz, Magnus von (Author) , Kloor, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 21 September 2020
In: Nature Communications
Year: 2020, Volume: 11, Pages: 1-13
ISSN:2041-1723
DOI:10.1038/s41467-020-18514-5
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41467-020-18514-5
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-020-18514-5
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Author Notes:Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L. Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz & Matthias Kloor
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Summary:The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) and to neoantigen-inducing translational frameshifts. Here, we develop a tool to quantify frameshift mutations in MSI colorectal and endometrial cancer.
Item Description:Gesehen am 23.09.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-020-18514-5

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