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Exploring whole-genome duplicate gene retention with complex genetic interaction analysis

Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interac...

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Main Authors: Kuzmin, Elena (Author) , VanderSluis, Benjamin (Author) , Ba, Alex N. Nguyen (Author) , Wang, Wen (Author) , Koch, Elizabeth N. (Author) , Usaj, Matej (Author) , Khmelinskii, Anton (Author) , Usaj, Mojca Mattiazzi (Author) , van Leeuwen, Jolanda (Author) , Kraus, Oren (Author) , Tresenrider, Amy (Author) , Pryszlak, Michael (Author) , Hu, Ming-Che (Author) , Varriano, Brenda (Author) , Costanzo, Michael (Author) , Knop, Michael (Author) , Moses, Alan (Author) , Myers, Chad L. (Author) , Andrews, Brenda J. (Author) , Boone, Charles (Author)
Format: Article (Journal)
Language:English
Published: 26 June 2020
In: Science
Year: 2020, Volume: 368, Issue: 6498
ISSN:1095-9203
DOI:10.1126/science.aaz5667
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.aaz5667
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Author Notes:Elena Kuzmin, Benjamin VanderSluis, Alex N. Nguyen Ba, Wen Wang, Elizabeth N. Koch, Matej Usaj, Anton Khmelinskii, Mojca Mattiazzi Usaj, Jolanda van Leeuwen, Oren Kraus, Amy Tresenrider, Michael Pryszlak, Ming-Che Hu, Brenda Varriano, Michael Costanzo, Michael Knop, Alan Moses, Chad L. Myers, Brenda J. Andrews, Charles Boone
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Summary:Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mutant, provides insight into their roles and a quantitative measure of their functional redundancy. Trigenic interaction analysis distinguishes two classes of paralogs: a more functionally divergent subset and another that retained more functional overlap. Gene feature analysis and modeling suggest that evolutionary trajectories of duplicated genes are dictated by combined functional and structural entanglement factors.
Item Description:Gesehen am 23.09.2020
Physical Description:Online Resource
ISSN:1095-9203
DOI:10.1126/science.aaz5667

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