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Alteration of light-dependent gene regulation by the absence of the RCO-1/RCM-1 repressor complex in the fungus Neurospora crassa

The activation of transcription by light in the fungus Neurospora crassa requires the White Collar Complex (WCC), a photoreceptor and transcription factor complex. After light reception two WCCs interact and bind the promoters of light-regulated genes to activate transcription. This process is regul...

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Bibliographic Details
Main Authors: Ruger-Herreros, Carmen (Author) , Gil-Sánchez, María del Mar (Author) , Sancar, Gencer (Author) , Brunner, Michael (Author) , Corrochano, Luis M. (Author)
Format: Article (Journal)
Language:English
Published: April 18, 2014
In: PLOS ONE
Year: 2014, Volume: 9, Issue: 4
ISSN:1932-6203
DOI:10.1371/journal.pone.0095069
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0095069
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095069
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Author Notes:Carmen Ruger-Herreros, María del Mar Gil-Sánchez, Gencer Sancar, Michael Brunner, Luis M. Corrochano
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Summary:The activation of transcription by light in the fungus Neurospora crassa requires the White Collar Complex (WCC), a photoreceptor and transcription factor complex. After light reception two WCCs interact and bind the promoters of light-regulated genes to activate transcription. This process is regulated by VVD, a small photoreceptor that disrupts the interaction between WCCs and leads to a reduction in transcription after long exposures to light. The N. crassa RCO-1/RCM-1 repressor complex is the homolog of the Tup1-Ssn6 repressor complex in yeast, and its absence modifies photoadaptation. We show that the absence of the RCO-1/RCM-1 repressor complex leads to several alterations in transcription that are gene-specific: an increase in the accumulation of mRNAs in the dark, a repression of transcription, and a derepression of transcription after long exposures to light.
Item Description:Gesehen am 25.09.2020
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0095069

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