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Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

African trypanosomes express three virtually identical non-selenium glutathione peroxidase (Px)-type enzymes which preferably detoxify lipid-derived hydroperoxides. As shown previously, bloodstream Trypanosoma brucei lacking the mitochondrial Px III display only a weak and transient proliferation de...

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Bibliographic Details
Main Authors: Schaffroth, Corinna (Author) , Nißen, Amrei (Author) , Benítez, Diego (Author) , Comini, Marcelo A. (Author) , Krauth-Siegel, Renate (Author)
Format: Article (Journal)
Language:English
Published: April 10, 2014
In: PLoS pathogens
Year: 2014, Volume: 10, Issue: 4
ISSN:1553-7374
DOI:10.1371/journal.ppat.1004075
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.ppat.1004075
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004075
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Author Notes:Corinna Hiller, Amrei Nissen, Diego Benítez, Marcelo A. Comini, R. Luise Krauth-Siegel
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Summary:African trypanosomes express three virtually identical non-selenium glutathione peroxidase (Px)-type enzymes which preferably detoxify lipid-derived hydroperoxides. As shown previously, bloodstream Trypanosoma brucei lacking the mitochondrial Px III display only a weak and transient proliferation defect whereas parasites that lack the cytosolic Px I and Px II undergo extremely fast lipid peroxidation and cell lysis. The phenotype can completely be rescued by supplementing the medium with the α-tocopherol derivative Trolox.
Item Description:Gesehen am 25.09.2020
Physical Description:Online Resource
ISSN:1553-7374
DOI:10.1371/journal.ppat.1004075

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