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Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

African trypanosomes express three virtually identical non-selenium glutathione peroxidase (Px)-type enzymes which preferably detoxify lipid-derived hydroperoxides. As shown previously, bloodstream Trypanosoma brucei lacking the mitochondrial Px III display only a weak and transient proliferation de...

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Bibliographische Detailangaben
Hauptverfasser: Schaffroth, Corinna (VerfasserIn) , Nißen, Amrei (VerfasserIn) , Benítez, Diego (VerfasserIn) , Comini, Marcelo A. (VerfasserIn) , Krauth-Siegel, Renate (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 10, 2014
In: PLoS pathogens
Year: 2014, Jahrgang: 10, Heft: 4
ISSN:1553-7374
DOI:10.1371/journal.ppat.1004075
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.ppat.1004075
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004075
Volltext
Verfasserangaben:Corinna Hiller, Amrei Nissen, Diego Benítez, Marcelo A. Comini, R. Luise Krauth-Siegel
Beschreibung
Zusammenfassung:African trypanosomes express three virtually identical non-selenium glutathione peroxidase (Px)-type enzymes which preferably detoxify lipid-derived hydroperoxides. As shown previously, bloodstream Trypanosoma brucei lacking the mitochondrial Px III display only a weak and transient proliferation defect whereas parasites that lack the cytosolic Px I and Px II undergo extremely fast lipid peroxidation and cell lysis. The phenotype can completely be rescued by supplementing the medium with the α-tocopherol derivative Trolox.
Beschreibung:Gesehen am 25.09.2020
Beschreibung:Online Resource
ISSN:1553-7374
DOI:10.1371/journal.ppat.1004075

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