The silicon trypanosome: a test case of iterative model extension in systems biology

The African trypanosome, Trypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolys...

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Main Authors:	Achcar, Fiona (Author) , Fadda, Abeer (Author) , Haanstra, Jurgen R. (Author) , Kerkhoven, Eduard J. (Author) , Kim, Dong-Hyun (Author) , Leroux, Alejandro E. (Author) , Papamarkou, Theodore (Author) , Rojas, Federico (Author) , Bakker, Barbara M. (Author) , Barrett, Michael P. (Author) , Clayton, Christine (Author) , Girolami, Mark (Author) , Krauth-Siegel, Renate (Author) , Matthews, Keith R. (Author) , Breitling, Rainer (Author)
Format:	Chapter/Article
Language:	English
Published:	4 May 2014
In:	Advances in microbial systems biology Year: 2014, Pages: 115-143
Online Access:	Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/B9780128001431000038
Author Notes:	Fiona Achcar, Abeer Fadda, Jurgen R. Haanstra, Eduard J. Kerkhoven, Dong-Hyun Kim, Alejandro E. Leroux, Theodore Papamarkou, Federico Rojas, Barbara M. Bakker, Michael P. Barrett, Christine Clayton, Mark Girolami, R. Luise Krauth-Siegel, Keith R. Matthews, Rainer Breitling