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High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol

Further improvement of outcome in childhood acute lymphoblastic leukemia could be achieved by identifying additional high-risk patients who may benefit from intensified treatment. We earlier identified PTPRC (CD45) gene expression as a potential new stratification marker and now analyzed the prognos...

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Main Authors: Cario, Gunnar (Author) , Rhein, Peter (Author) , Mitlöhner, Rita (Author) , Zimmermann, Martin (Author) , Bandapalli, Obul Reddy (Author) , Romey, Renja (Author) , Moericke, Anja (Author) , Ludwig, Wolf-Dieter (Author) , Ratei, Richard (Author) , Muckenthaler, Martina (Author) , Kulozik, Andreas (Author) , Schrappe, Martin (Author) , Stanulla, Martin (Author) , Karawajew, Leonid (Author)
Format: Article (Journal)
Language:English
Published: January 2014
In: Haematologica
Year: 2014, Volume: 99, Issue: 1, Pages: 103-110
ISSN:1592-8721
DOI:10.3324/haematol.2013.090225
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2013.090225
Verlag, lizenzpflichtig, Volltext: https://haematologica.org/article/view/6885
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Author Notes:Gunnar Cario, Peter Rhein, Rita Mitlöhner, Martin Zimmermann, Obul R. Bandapalli, Renja Romey, Anja Moericke, Wolf-Dieter Ludwig, Richard Ratei, Martina U. Muckenthaler, Andreas E. Kulozik, Martin Schrappe, Martin Stanulla, and Leonid Karawajew
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Summary:Further improvement of outcome in childhood acute lymphoblastic leukemia could be achieved by identifying additional high-risk patients who may benefit from intensified treatment. We earlier identified PTPRC (CD45) gene expression as a potential new stratification marker and now analyzed the prognostic relevance of CD45 protein expression. CD45 was measured by flow cytometry in 1065 patients treated according to the ALL-BFM-2000 protocol. The 75th percentile was used as cut-off to distinguish a CD45-high from a CD45-low group. As mean CD45 expression was significantly higher in T-cell acute lymphoblastic leukemia than in B-cell-precursor acute lymphoblastic leukemia (P
Item Description:Gesehen am 09.10.2020
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.2013.090225

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