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Antimicrobial activity of water-soluble triazole phenazine clickamers against E. coli

The antimicrobial potency of phenazine derivatives is attenuated by their inherently hydrophobic nature, complicating their use as antibiotic drugs. We have analyzed the cytotoxicity and mode of action of water-soluble bis-triazolyl phenazines against E. coli and a human epithelial (HaCat) cell line...

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Bibliographic Details
Main Authors: Hayden, Steven C. (Author) , Bryant, Jonathan (Author) , Mackey, Megan A. (Author) , Höfer, Katharina (Author) , Lindner, Benjamin (Author) , Nguyen, Vanessa P. (Author) , Jäschke, Andres (Author) , Bunz, Uwe H. F. (Author)
Format: Article (Journal)
Language:English
Published: 2014
In: Chemistry - a European journal
Year: 2014, Volume: 20, Issue: 3, Pages: 719-723
ISSN:1521-3765
DOI:10.1002/chem.201303353
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/chem.201303353
Verlag, lizenzpflichtig, Volltext: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201303353
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Author Notes:Steven C. Hayden, Jonathan J. Bryant, Megan A. Mackey, Katharina Höfer, Benjamin D. Lindner, Vanessa P. Nguyen, Andres Jäschke, and Uwe H.F. Bunz
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Summary:The antimicrobial potency of phenazine derivatives is attenuated by their inherently hydrophobic nature, complicating their use as antibiotic drugs. We have analyzed the cytotoxicity and mode of action of water-soluble bis-triazolyl phenazines against E. coli and a human epithelial (HaCat) cell line. We observed complete inhibition of bacterial growth over concentration ranges that do not affect the viability of human epithelial cells. Confocal fluorescence microscopy revealed a high degree of interaction between the phenazine compounds and E. coli, as well as evidence of membrane damage in phenazine-treated E. coli. Additional data suggests that the potency of these particular water-soluble phenazine compounds does not result from the production of reactive oxygen species, but rather from cytotoxic interference with metabolic electron-transfer cascades.
Item Description:Published online on December 11, 2013
Gesehen am 13.10.2020
Physical Description:Online Resource
ISSN:1521-3765
DOI:10.1002/chem.201303353

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