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Unraveling liver complexity from molecular to organ level: challenges and perspectives

Biological responses are determined by information processing at multiple and highly interconnected scales. Within a tissue the individual cells respond to extracellular stimuli by regulating intracellular signaling pathways that in turn determine cell fate decisions and influence the behavior of ne...

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Hauptverfasser: D'Alessandro, Lorenza (VerfasserIn) , Hoehme, S. (VerfasserIn) , Henney, A. (VerfasserIn) , Drasdo, D. (VerfasserIn) , Klingmüller, Ursula (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2015
In: Progress in biophysics & molecular biology
Year: 2014, Jahrgang: 117, Heft: 1, Pages: 78-86
ISSN:1873-1732
DOI:10.1016/j.pbiomolbio.2014.11.005
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.pbiomolbio.2014.11.005
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0079610714001849
Volltext
Verfasserangaben:L.A. D'Alessandro, S. Hoehme, A. Henney, D. Drasdo, U. Klingmüller
Beschreibung
Zusammenfassung:Biological responses are determined by information processing at multiple and highly interconnected scales. Within a tissue the individual cells respond to extracellular stimuli by regulating intracellular signaling pathways that in turn determine cell fate decisions and influence the behavior of neighboring cells. As a consequence the cellular responses critically impact tissue composition and architecture. Understanding the regulation of these mechanisms at different scales is key to unravel the emergent properties of biological systems. In this perspective, a multidisciplinary approach combining experimental data with mathematical modeling is introduced. We report the approach applied within the Virtual Liver Network to analyze processes that regulate liver functions from single cell responses to the organ level using a number of examples. By facilitating interdisciplinary collaborations, the Virtual Liver Network studies liver regeneration and inflammatory processes as well as liver metabolic functions at multiple scales, and thus provides a suitable example to identify challenges and point out potential future application of multi-scale systems biology.
Beschreibung:Available online 26 November 2014
Gesehen am 14.10.2020
Beschreibung:Online Resource
ISSN:1873-1732
DOI:10.1016/j.pbiomolbio.2014.11.005

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