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CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk

Cholesteryl ester transfer protein (CETP) is a component of the high density lipoprotein (HDL). Variations in the CETP gene may cause CETP deficiency, which is characterized by decreased mass and activity of the protein as well as altered HDL and LDL levels. We investigated the effect of three putat...

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Main Authors: Qureischie, Homeira (Author) , Heun, Reinhard (Author) , Lütjohann, Dieter (Author) , Popp, Julius (Author) , Jessen, Frank (Author) , Ledschbor-Frahnert, Christine (Author) , Thiele, Holger (Author) , Maier, Wolfgang (Author) , Hentschel, Frank (Author) , Kelemen, Peter (Author) , Kölsch, Heike (Author)
Format: Article (Journal)
Language:English
Published: 22 July 2008
In: Brain research
Year: 2008, Volume: 1232, Pages: 1-6
ISSN:1872-6240
DOI:10.1016/j.brainres.2008.07.047
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.brainres.2008.07.047
Verlag: http://www.sciencedirect.com/science/article/pii/S0006899308017502
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Author Notes:Homeira Qureischie, Reinhard Heun, Dieter Lütjohann, Julius Popp, Frank Jessen, Christine Ledschbor-Frahnert, Holger Thiele, Wolfgang Maier, Frank Hentschel, Peter Kelemen, Heike Kölsch
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Summary:Cholesteryl ester transfer protein (CETP) is a component of the high density lipoprotein (HDL). Variations in the CETP gene may cause CETP deficiency, which is characterized by decreased mass and activity of the protein as well as altered HDL and LDL levels. We investigated the effect of three putative functional CETP polymorphisms (-1946 VNTR, C-629A and I405V) on the risk of Alzheimer's disease (AD) and on cholesterol, lathosterol and 24S-hydroxycholesterol levels in CSF and plasma of AD patients and controls. None of the investigated CETP polymorphisms or haplotypes had any effect on the risk of AD. However, we found that a three marker CETP haplotype (L/C/V) influenced CSF levels of lathosterol and 24S-hydroxycholesterol as well as plasma levels of total cholesterol in controls but not in AD patients. Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk.
Item Description:Gesehen am 15.10.2020
Physical Description:Online Resource
ISSN:1872-6240
DOI:10.1016/j.brainres.2008.07.047

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