Copper-boxmi complexes as highly enantioselective catalysts for electrophilic trifluoromethylthiolations
The enantioselective trifluoromethylthiolation of β-ketoesters using chiral copper-boxmi complexes as catalysts is reported. A number of α-SCF3-substituted β-ketoesters have been obtained with up to >99 % enantiomeric excess (ee), and the trifluoromethylthiolated products were then transformed di...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2014
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| In: |
Chemistry - a European journal
Year: 2013, Volume: 20, Issue: 1, Pages: 93-97 |
| ISSN: | 1521-3765 |
| DOI: | 10.1002/chem.201303641 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/chem.201303641 Verlag, lizenzpflichtig, Volltext: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201303641 
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| Author Notes: | Qing-Hai Deng, Christoph Rettenmeier, Hubert Wadepohl, and Lutz H. Gade |
| Summary: | The enantioselective trifluoromethylthiolation of β-ketoesters using chiral copper-boxmi complexes as catalysts is reported. A number of α-SCF3-substituted β-ketoesters have been obtained with up to >99 % enantiomeric excess (ee), and the trifluoromethylthiolated products were then transformed diastereoselectively to α-SCF3-β-hydroxyesters with two adjacent quaternary stereocenters. |
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| Item Description: | Published online on December 11, 2013 Gesehen am 15.10.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1521-3765 |
| DOI: | 10.1002/chem.201303641 |