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Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice

Mutations that result in the defective trafficking of γ2 subunit containing GABAA receptors (γ2-GABAARs) are known to reduce synaptic inhibition. Whether perturbed clustering of non-mutated GABAARs similarly reduces synaptic inhibition in vivo is less clear. In this study we provide evidence that th...

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Main Authors: O'Sullivan, Gregory A. (Author) , Jedlicka, Peter (Author) , Chen, Hong-Xing (Author) , Kalbouneh, Hebah (Author) , Ippolito, Angelo (Author) , Deller, Thomas (Author) , Nawrotzki, Ralph (Author) , Kuhse, Jochen (Author) , Kalaidzidis, Yannis L. (Author) , Kirsch, Joachim (Author) , Schwarzacher, Stephan W. (Author) , Betz, Heinrich (Author)
Format: Article (Journal)
Language:English
Published: 30 Januar 2016
In: Molecular and cellular neuroscience
Year: 2016, Volume: 72, Pages: 101-113
ISSN:1095-9327
DOI:10.1016/j.mcn.2016.01.010
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mcn.2016.01.010
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1044743116300100
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Author Notes:Gregory A. O'Sullivan, Peter Jedlicka, Hong-Xing Chen, Heba Kalbouneh, Angelo Ippolito, Thomas Deller, Ralph A. Nawrotzki, Jochen Kuhse, Yannis L. Kalaidzidis, Joachim Kirsch, Stephan W. Schwarzacher, Heinrich Betz
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Summary:Mutations that result in the defective trafficking of γ2 subunit containing GABAA receptors (γ2-GABAARs) are known to reduce synaptic inhibition. Whether perturbed clustering of non-mutated GABAARs similarly reduces synaptic inhibition in vivo is less clear. In this study we provide evidence that the loss of postsynaptic γ2-GABAARs upon postnatal ablation of gephyrin, the major scaffolding protein of inhibitory postsynapses, from mature principal neurons within the forebrain results in reduced induction of long-term potentiation (LTP) and impaired network excitability within the hippocampal dentate gyrus. The preferential reduction in not only synaptic γ2-GABAAR cluster number at dendritic sites but also the decrease in γ2-GABAAR density within individual clusters at dendritic inhibitory synapses suggests that distal synapses are more sensitive to the loss of gephyrin expression than proximal synapses. The fact that these mice display behavioural features of anxiety and epilepsy emphasises the importance of postsynaptic γ2-GABAAR clustering for synaptic inhibition.
Item Description:Im Titel ist der Buchstabe A nach GABA tiefgestellt
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Physical Description:Online Resource
ISSN:1095-9327
DOI:10.1016/j.mcn.2016.01.010

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