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Early post-operative acute phase response in patients with early graft dysfunction is predictive of 6-month and 12-month mortality in liver transplant recipients

Early allograft dysfunction (EAD) after liver transplantation is mostly a reversible event caused by factors related to ischemia/reperfusion (I/R) injury. EAD represents a hepatic injury associated with pre- and early post-transplant inflammatory cytokine responses. Aim of the present study was to e...

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Main Authors: Oweira, Hani (Author) , Lahdou, Imad (Author) , Daniel, Volker (Author) , Opelz, Gerhard (Author) , Schmidt, Jan (Author) , Zidan, Ahmed (Author) , Mehrabi, Arianeb (Author) , Sadeghi, Mahmoud (Author)
Format: Article (Journal)
Language:English
Published: 27 July 2016
In: Human immunology
Year: 2016, Volume: 77, Issue: 10, Pages: 952-960
ISSN:1879-1166
DOI:10.1016/j.humimm.2016.07.234
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.humimm.2016.07.234
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0198885916303883
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Author Notes:Hani Oweira, Imad Lahdou, Volker Daniel, Gerhard Opelz, Jan Schmidt, Ahmed Zidan, Arianeb Mehrabi, Mahmoud Sadeghi
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Summary:Early allograft dysfunction (EAD) after liver transplantation is mostly a reversible event caused by factors related to ischemia/reperfusion (I/R) injury. EAD represents a hepatic injury associated with pre- and early post-transplant inflammatory cytokine responses. Aim of the present study was to evaluate the prognostic and diagnostic value of CRP in liver transplant recipients with EAD. - Materials and methods - Forty-seven patients with EAD were compared with 115 non-EAD patients. Pre- and post-transplant parameters were analyzed. EAD was defined based on postoperative liver function tests such as INR, bilirubin and liver enzymes. Statistical analysis was performed using SPSS version 18.0. - Results - Pre-transplant liver enzyme were not significantly different in the two groups. At day 3, 5 and 10 post-transplant CRP was significantly higher in patients with EAD than in non-EAD patients (pâ©˝0.001 for all investigations) and remained consistently high in patients with EAD and low in non-EAD patients. EAD patients with high CRP at post-transplant days 3 and 5 showed lower survival at 6-month and 12-month post-transplant than patients with low CRP. - Conclusion - Our results indicate a prognostic and diagnostic value of CRP in patients with early graft dysfunction and predict 6-month and 12-month mortality in liver transplant recipients.
Item Description:Gesehen am 16.10.2020
Physical Description:Online Resource
ISSN:1879-1166
DOI:10.1016/j.humimm.2016.07.234

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