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RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism

Cholesterol metabolism is altered in Alzheimer's disease (AD). The nuclear hormone receptor Retinoic X Receptor a (RXRa) is a member of the nuclear ligand-activated transcription factor family. RXRs are key regulators of cholesterol synthesis and thus cholesterol metabolism. We performed a syst...

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Main Authors: Kölsch, Heike (Author) , Lütjohann, Dieter (Author) , Jessen, Frank (Author) , Popp, Julius (Author) , Hentschel, Frank (Author) , Kelemen, Peter (Author) , Friedrichs, Silvia (Author) , Maier, T. A. Wolfgang (Author) , Heun, Reinhard (Author)
Format: Article (Journal)
Language:English
Published: 24 March 2009
In: Journal of cellular and molecular medicine
Year: 2009, Volume: 13, Issue: 3, Pages: 589-598
ISSN:1582-4934
DOI:10.1111/j.1582-4934.2009.00383.x
Online Access:Verlag, Volltext: https://doi.org/10.1111/j.1582-4934.2009.00383.x
Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1582-4934.2009.00383.x
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Author Notes:Heike Kölsch, Dieter Lütjohann, Frank Jessen, Julius Popp, Frank Hentschel, Peter Kelemen, Silvia Friedrichs, T.A. Wolfgang Maier, Reinhard Heun
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Summary:Cholesterol metabolism is altered in Alzheimer's disease (AD). The nuclear hormone receptor Retinoic X Receptor a (RXRa) is a member of the nuclear ligand-activated transcription factor family. RXRs are key regulators of cholesterol synthesis and thus cholesterol metabolism. We performed a systematic screen for gene variants in the RXRA gene. The effect of these gene variants on the risk of AD was investigated in 405 AD patients (mean age: 74.27 ± 9.37 years; female 78.6%) and 347 controls (mean age: 73.26 ± 8.37 years; female 57.2%). Furthermore, the influence of RXRA gene variants on CSF and plasma levels of cholesterol, lathosterol and 24S-hydroxycholesterol were evaluated. One of the identified seven SNPs in RXRA influenced AD risk in our single marker analysis (rs3132293: P= 0.006). Haplotype analysis identified a three-marker haplotype (TGC) consisting of rs3118570, rs1536475 and rs3132293, which decreased the risk of AD (P= 0.009). The single marker rs3132293 (P= 0.026) and the TGC haplotype (P= 0.026) influenced CSF lathosterol levels in non-demented controls, and cholesterol levels in the combined sample comprising AD patients and controls (Rs3132293: P= 0.050; TGC haplotype: P= 0.035). 24S-Hydroxycholesterol CSF and plasma levels were also influenced by rs3132293 (CSF: P= 0.004; plasma: P= 0.001) and the TGC haplotype (CSF: P= 0.004; plasma: P= 0.002); this effect was most pronounced in AD patients (rs3132293: CSF: P= 0.009, plasma: P= 0.002; TGC haplotype: CSF: P= 0.019, plasma: P= 0.005). Our results suggest that RXRA gene variants might act as risk factor for AD via an influence on cerebral cholesterol metabolism.
Item Description:Gesehen am 19.10.2020
Physical Description:Online Resource
ISSN:1582-4934
DOI:10.1111/j.1582-4934.2009.00383.x

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