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Effect of autologous adipose tissue-derived mesenchymal stem cells on neovascularization of artificial equine tendon lesions

Aims: To investigate whether autologous adipose tissue-derived mesenchymal stem cells (AT-MSCs) treatment of tendon lesions increases neovascularization during tendon healing. Materials & methods: A standardized surgical model was used to create lesions in both front limb superficial digital fle...

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Main Authors: Conze, Philipp (Author) , van Schie, Hans TM (Author) , Weeren, René van (Author) , Staszyk, Carsten (Author) , Conrad, Sabine (Author) , Skutella, Thomas (Author) , Hopster, Klaus (Author) , Rohn, Karl (Author) , Stadler, Peter (Author) , Geburek, Florian (Author)
Format: Article (Journal)
Language:English
Published: 28 Nov 2014
In: Regenerative medicine
Year: 2014, Volume: 9, Issue: 6, Pages: 743-757
ISSN:1746-076X
DOI:10.2217/rme.14.55
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2217/rme.14.55
Verlag, lizenzpflichtig, Volltext: https://www.futuremedicine.com/doi/10.2217/rme.14.55
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Author Notes:Philipp Conze, Hans TM van Schie, René van Weeren, Carsten Staszyk, Sabine Conrad, Thomas Skutella, Klaus Hopster, Karl Rohn, Peter Stadler & Florian Geburek
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Summary:Aims: To investigate whether autologous adipose tissue-derived mesenchymal stem cells (AT-MSCs) treatment of tendon lesions increases neovascularization during tendon healing. Materials & methods: A standardized surgical model was used to create lesions in both front limb superficial digital flexor tendons (SDFTs) of nine horses. Either AT-MSCs or control substance was injected intralesionally 2 weeks post-surgery. Color Doppler ultrasonography of SDFTs was performed at regular intervals. Horses were euthanized 22 weeks post-treatment and SDFTs were harvested for histology. Results: The color Doppler ultrasonography signal was significantly more extensive at 2 weeks post-treatment and the number of vessels counted on histologic slides was significantly higher at 22 weeks post-treatment in AT-MSC-treated SDFTs. Conclusion: Our findings indicate that AT-MSC treatment has a beneficial effect on neovascularization of healing tendons.
Item Description:Gesehen am 20.10.2020
Physical Description:Online Resource
ISSN:1746-076X
DOI:10.2217/rme.14.55

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