Effect of autologous adipose tissue-derived mesenchymal stem cells on neovascularization of artificial equine tendon lesions
Aims: To investigate whether autologous adipose tissue-derived mesenchymal stem cells (AT-MSCs) treatment of tendon lesions increases neovascularization during tendon healing. Materials & methods: A standardized surgical model was used to create lesions in both front limb superficial digital fle...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 Nov 2014
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| In: |
Regenerative medicine
Year: 2014, Jahrgang: 9, Heft: 6, Pages: 743-757 |
| ISSN: | 1746-076X |
| DOI: | 10.2217/rme.14.55 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2217/rme.14.55 Verlag, lizenzpflichtig, Volltext: https://www.futuremedicine.com/doi/10.2217/rme.14.55 
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| Verfasserangaben: | Philipp Conze, Hans TM van Schie, René van Weeren, Carsten Staszyk, Sabine Conrad, Thomas Skutella, Klaus Hopster, Karl Rohn, Peter Stadler & Florian Geburek |
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| 245 | 1 | 0 | |a Effect of autologous adipose tissue-derived mesenchymal stem cells on neovascularization of artificial equine tendon lesions |c Philipp Conze, Hans TM van Schie, René van Weeren, Carsten Staszyk, Sabine Conrad, Thomas Skutella, Klaus Hopster, Karl Rohn, Peter Stadler & Florian Geburek |
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| 520 | |a Aims: To investigate whether autologous adipose tissue-derived mesenchymal stem cells (AT-MSCs) treatment of tendon lesions increases neovascularization during tendon healing. Materials & methods: A standardized surgical model was used to create lesions in both front limb superficial digital flexor tendons (SDFTs) of nine horses. Either AT-MSCs or control substance was injected intralesionally 2 weeks post-surgery. Color Doppler ultrasonography of SDFTs was performed at regular intervals. Horses were euthanized 22 weeks post-treatment and SDFTs were harvested for histology. Results: The color Doppler ultrasonography signal was significantly more extensive at 2 weeks post-treatment and the number of vessels counted on histologic slides was significantly higher at 22 weeks post-treatment in AT-MSC-treated SDFTs. Conclusion: Our findings indicate that AT-MSC treatment has a beneficial effect on neovascularization of healing tendons. | ||
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| 700 | 1 | |a Conrad, Sabine |e VerfasserIn |4 aut | |
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