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From stereodynamics to high-throughput screening of catalysed reactions

Characterising chemical reactions by kinetic analysis is of fundamental importance to experimentally obtain insights into reaction mechanisms. Based on such investigations reactions can be optimised and improved catalysts designed. Enhanced reaction conditions may drastically increase the performanc...

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Bibliographic Details
Main Authors: Stockinger, Skrollan Carina (Author) , Gmeiner, Julia Renate (Author) , Zawatzky, Kerstin (Author) , Troendlin, Johannes (Author) , Trapp, Oliver (Author)
Format: Article (Journal)
Language:English
Published: 29 July 2014
In: Chemical communications
Year: 2014, Volume: 50, Issue: 92, Pages: 14301-14309
ISSN:1364-548X
DOI:10.1039/C4CC04892J
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C4CC04892J
Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2014/cc/c4cc04892j
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Author Notes:Skrollan Stockinger, Julia Gmeiner, Kerstin Zawatzky, Johannes Troendlin and Oliver Trapp
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Summary:Characterising chemical reactions by kinetic analysis is of fundamental importance to experimentally obtain insights into reaction mechanisms. Based on such investigations reactions can be optimised and improved catalysts designed. Enhanced reaction conditions may drastically increase the performance of the reaction in terms of yield and (enantio-) selectivity. Understanding reaction kinetics in more complex systems involving adaptive chemical and dynamic systems on a molecular level as shown here is even more challenging. Here we review recent developments in monitoring reactions including the dynamic interconversion of stereoisomers by integrating (catalysed) reactions and chemical analysis in on-column reaction chromatographic devices. These recent developments allow rapid screening of reactions in great detail and are a central tool in determining reaction pathways and to understand how to control the stereodynamics of chiral molecules.
Item Description:Gesehen am 20.10.2020
Physical Description:Online Resource
ISSN:1364-548X
DOI:10.1039/C4CC04892J

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