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Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex®

Deregulated activation of mucosal lamina propria T cells plays a central role in the pathogenesis of intestinal inflammation. One of the means to attenuate T cell activation is by blocking the CD28/CD80 co-stimulatory pathway. Here we investigate RhuDex®, a small molecule that binds to human CD80, f...

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Main Authors: Heninger, Anne-Kristin (Author) , Wentrup, Sabine (Author) , Saeedi, Mohammed al (Author) , Schiessling, Serin (Author) , Giese, Thomas (Author) , Wartha, Florian (Author) , Meuer, Stefan (Author) , Schröder-Braunstein, Jutta (Author)
Format: Article (Journal)
Language:English
Published: 3 November 2014
In: Immunity, Inflammation and Disease
Year: 2014, Volume: 2, Issue: 3, Pages: 166-180
ISSN:2050-4527
DOI:10.1002/iid3.34
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/iid3.34
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/iid3.34
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Author Notes:Anne-Kristin Heninger, Sabine Wentrup, Mohammed Al‐Saeedi, Serin Schiessling, Thomas Giese, Florian Wartha, Stefan Meuer, & Jutta Schröder‐Braunstein
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Summary:Deregulated activation of mucosal lamina propria T cells plays a central role in the pathogenesis of intestinal inflammation. One of the means to attenuate T cell activation is by blocking the CD28/CD80 co-stimulatory pathway. Here we investigate RhuDex®, a small molecule that binds to human CD80, for its effects on the activation of lamina propria T cells employing a gut-culture model of inflammation.
Item Description:Gesehen am 20.10.2020
Physical Description:Online Resource
ISSN:2050-4527
DOI:10.1002/iid3.34

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