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A defense pathway linking plasma membrane and chloroplasts and co-opted by pathogens

Chloroplasts are crucial players in the activation of defensive hormonal responses during plant-pathogen interactions. Here, we show that a plant virus-encoded protein re-localizes from the plasma membrane to chloroplasts upon activation of plant defense, interfering with the chloroplast-dependent a...

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Main Authors: Medina-Puche, Laura (Author) , Tan, Huang (Author) , Dogra, Vivek (Author) , Wu, Mengshi (Author) , Rosas-Diaz, Tabata (Author) , Wang, Liping (Author) , Ding, Xue (Author) , Zhang, Dan (Author) , Fu, Xing (Author) , Kim, Chanhong (Author) , Lozano-Duran, Rosa (Author)
Format: Article (Journal)
Language:English
Published: 24 August 2020
In: Cell
Year: 2020, Volume: 182, Issue: 5, Pages: 1109-1124, e1-e25
ISSN:1097-4172
DOI:10.1016/j.cell.2020.07.020
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2020.07.020
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0092867420308850
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Author Notes:Laura Medina-Puche, Huang Tan, Vivek Dogra, Mengshi Wu, Tabata Rosas-Diaz, Liping Wang, Xue Ding, Dan Zhang, Xing Fu, Chanhong Kim, Rosa Lozano-Duran
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Summary:Chloroplasts are crucial players in the activation of defensive hormonal responses during plant-pathogen interactions. Here, we show that a plant virus-encoded protein re-localizes from the plasma membrane to chloroplasts upon activation of plant defense, interfering with the chloroplast-dependent anti-viral salicylic acid (SA) biosynthesis. Strikingly, we have found that plant pathogens from different kingdoms seem to have convergently evolved to target chloroplasts and impair SA-dependent defenses following an association with membranes, which relies on the co-existence of two subcellular targeting signals, an N-myristoylation site and a chloroplast transit peptide. This pattern is also present in plant proteins, at least one of which conversely activates SA defenses from the chloroplast. Taken together, our results suggest that a pathway linking plasma membrane to chloroplasts and activating defense exists in plants and that such pathway has been co-opted by plant pathogens during host-pathogen co-evolution to promote virulence through suppression of SA responses.
Item Description:Gesehen am 22.10.2020
Physical Description:Online Resource
ISSN:1097-4172
DOI:10.1016/j.cell.2020.07.020

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