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Recurrent pseudoprogression in isocitrate dehydrogenase 1 mutant glioblastoma

In a subset of glioblastoma (GBM) patients, the differentiation between tumor progression and tumor pseudoprogression (PsP) is challenging. This case describes a male patient suffering from isocitrate dehydrogenase 1 (IDH1) mutant GBM who demonstrated an increasing contrast-enhancing (CE) lesion on...

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Bibliographic Details
Main Authors: Kebir, Sied (Author) , Giordano, Frank Anton (Author)
Format: Article (Journal)
Language:English
Published: July 2018
In: Journal of clinical neuroscience
Year: 2018, Volume: 53, Pages: 255-258
ISSN:1532-2653
DOI:10.1016/j.jocn.2018.04.056
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jocn.2018.04.056
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0967586818303345
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Author Notes:Sied Kebir, Laurèl Rauschenbach, Gerrit H. Gielen, Niklas Schäfer, Theophilos Tzaridis, Björn Scheffler, Frank A. Giordano, Lazaros Lazaridis, Ulrich Herrlinger, Martin Glas
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Summary:In a subset of glioblastoma (GBM) patients, the differentiation between tumor progression and tumor pseudoprogression (PsP) is challenging. This case describes a male patient suffering from isocitrate dehydrogenase 1 (IDH1) mutant GBM who demonstrated an increasing contrast-enhancing (CE) lesion on a cranial magnetic resonance imaging (cMRI) scan 8months after radiochemotherapy. In accordance with the response assessment in neuro-oncology (RANO) criteria, the cMRI lesion was classified as recurrent tumor, although 18F-fluoroethyl-L-tyrosine positron emission tomography (18F-FET-PET) did not indicate vital tumor tissue. The patient underwent re-surgery but histopathology only revealed reactive and necrotic tissue, consistent with PsP. Nine weeks after complete resection of the CE lesion, a new lesion emerged that later regressed in the follow-up cMRI scans, thereby retrospectively establishing the diagnosis of recurrent PsP.
Item Description:Gesehen am 22.10.2020
Physical Description:Online Resource
ISSN:1532-2653
DOI:10.1016/j.jocn.2018.04.056

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