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Biosimilar G-CSF based mobilization of peripheral blood hematopoietic stem cells for autologous and allogeneic stem cell transplantation

The use of granulocyte colony stimulating factor (G-CSF) biosimilars for peripheral blood hematopoietic stem cell (PBSC) mobilization has stimulated an ongoing debate regarding their efficacy and safety. However, the use of biosimilar G-CSF was approved by the European Medicines Agency (EMA) for all...

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Main Authors: Schmitt, Michael (Author) , Publicover, Amy (Author) , Orchard, Kim H (Author) , Görlach, Matthias (Author) , Wang, Lei (Author) , Schmitt, Anita (Author) , Mani, Jiju (Author) , Tsirigotis, Panagiotis (Author) , Kuriakose, Reeba (Author) , Nagler, Arnon (Author)
Format: Article (Journal)
Language:English
Published: 2014.01.23
In: Theranostics
Year: 2014, Volume: 4, Issue: 3, Pages: 280-289
ISSN:1838-7640
DOI:10.7150/thno.7752
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7150/thno.7752
Verlag, lizenzpflichtig, Volltext: http://www.thno.org/v04p0280.htm
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Author Notes:Michael Schmitt, Amy Publicover, Kim H Orchard, Matthias Görlach, Lei Wang, Anita Schmitt, Jiju Mani, Panagiotis Tsirigotis, Reeba Kuriakose, Arnon Nagler
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Summary:The use of granulocyte colony stimulating factor (G-CSF) biosimilars for peripheral blood hematopoietic stem cell (PBSC) mobilization has stimulated an ongoing debate regarding their efficacy and safety. However, the use of biosimilar G-CSF was approved by the European Medicines Agency (EMA) for all the registered indications of the originator G-CSF (Neupogen®) including mobilization of stem cells. Here, we performed a comprehensive review of published reports on the use of biosimilar G-CSF covering patients with hematological malignancies as well as healthy donors that underwent stem cell mobilization at multiple centers using site-specific non-randomized regimens with a biosimilar G-CSF in the autologous and allogeneic setting.
Item Description:Gesehen am 27.10.2020
Physical Description:Online Resource
ISSN:1838-7640
DOI:10.7150/thno.7752

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