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Biosimilar G-CSF based mobilization of peripheral blood hematopoietic stem cells for autologous and allogeneic stem cell transplantation

The use of granulocyte colony stimulating factor (G-CSF) biosimilars for peripheral blood hematopoietic stem cell (PBSC) mobilization has stimulated an ongoing debate regarding their efficacy and safety. However, the use of biosimilar G-CSF was approved by the European Medicines Agency (EMA) for all...

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Bibliographische Detailangaben
Hauptverfasser: Schmitt, Michael (VerfasserIn) , Publicover, Amy (VerfasserIn) , Orchard, Kim H (VerfasserIn) , Görlach, Matthias (VerfasserIn) , Wang, Lei (VerfasserIn) , Schmitt, Anita (VerfasserIn) , Mani, Jiju (VerfasserIn) , Tsirigotis, Panagiotis (VerfasserIn) , Kuriakose, Reeba (VerfasserIn) , Nagler, Arnon (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2014.01.23
In: Theranostics
Year: 2014, Jahrgang: 4, Heft: 3, Pages: 280-289
ISSN:1838-7640
DOI:10.7150/thno.7752
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7150/thno.7752
Verlag, lizenzpflichtig, Volltext: http://www.thno.org/v04p0280.htm
Volltext
Verfasserangaben:Michael Schmitt, Amy Publicover, Kim H Orchard, Matthias Görlach, Lei Wang, Anita Schmitt, Jiju Mani, Panagiotis Tsirigotis, Reeba Kuriakose, Arnon Nagler
Beschreibung
Zusammenfassung:The use of granulocyte colony stimulating factor (G-CSF) biosimilars for peripheral blood hematopoietic stem cell (PBSC) mobilization has stimulated an ongoing debate regarding their efficacy and safety. However, the use of biosimilar G-CSF was approved by the European Medicines Agency (EMA) for all the registered indications of the originator G-CSF (Neupogen®) including mobilization of stem cells. Here, we performed a comprehensive review of published reports on the use of biosimilar G-CSF covering patients with hematological malignancies as well as healthy donors that underwent stem cell mobilization at multiple centers using site-specific non-randomized regimens with a biosimilar G-CSF in the autologous and allogeneic setting.
Beschreibung:Gesehen am 27.10.2020
Beschreibung:Online Resource
ISSN:1838-7640
DOI:10.7150/thno.7752

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