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Mesenchymal stem cells maintain their defining stem cell characteristics after treatment with cisplatin

Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show...

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Main Authors: Nicolay, Nils (Author) , Lopez Perez, Ramon (Author) , Rühle, Alexander (Author) , Trinh, Thuy (Author) , Sisombath, Sonevisay (Author) , Weber, Klaus-Josef (Author) , Ho, Anthony Dick (Author) , Debus, Jürgen (Author) , Saffrich, Rainer (Author) , Huber, Peter E. (Author)
Format: Article (Journal)
Language:English
Published: 25 January 2016
In: Scientific reports
Year: 2016, Volume: 6, Pages: 20035
ISSN:2045-2322
DOI:10.1038/srep20035
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/srep20035
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/srep20035
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Author Notes:Nils H. Nicolay, Ramon Lopez Perez, Alexander Rühle, Thuy Trinh, Sonevisay Sisombath, Klaus-Josef Weber, Anthony D. Ho, Jürgen & Debus, Rainer
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Summary:Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels comparable to these of differentiated fibroblasts. Cisplatin did not affect cellular morphology, adhesion or induction of apoptosis in MSCs. The potential for differentiation was preserved after exposure to cisplatin and established MSC surface markers were observed to be stably expressed irrespective of cisplatin treatment. Cytoskeletal rearrangements and high expression levels of individual heat shock proteins were detected in MSCs and may be partly responsible for the observed cisplatin resistance. The cisplatin-resistant phenotype of human MSCs supports the concept of further investigating these stem cells as a potential treatment option for cisplatin-induced tissue damage.
Item Description:Gesehen am 27.10.2020
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/srep20035

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