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International consensus definition of DNA methylation subgroups in juvenile myelomonocytic leukemia

Known clinical and genetic markers have limitations in predicting disease course and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation (DNAme) patterns in JMML have correlated with outcome across multiple studies, suggesting it as a biomarker to improve patient stratification. Howe...

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Main Authors: Schönung, Maximilian (Author) , Meyer, Julia (Author) , Nöllke, Peter (Author) , Olshen, Adam B. (Author) , Hartmann, Mark (Author) , Murakami, Norihiro (Author) , Wakamatsu, Manabu (Author) , Okuno, Yusuke (Author) , Plass, Christoph (Author) , Loh, Mignon L. (Author) , Niemeyer, Charlotte (Author) , Muramatsu, Hideki (Author) , Flotho, Christian (Author) , Stieglitz, Elliot (Author) , Lipka, Daniel (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Clinical cancer research
Year: 2020, Volume: 27, Issue: 1, Pages: 158-168
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-20-3184
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-20-3184
Verlag, lizenzpflichtig, Volltext: https://clincancerres.aacrjournals.org/content/early/2020/11/02/1078-0432.CCR-20-3184
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Author Notes:Maximilian Schönung, Julia Meyer, Peter Nöllke, Adam B. Olshen, Mark Hartmann, Norihiro Murakami, Manabu Wakamatsu, Yusuke Okuno, Christoph Plass, Mignon L. Loh, Charlotte M. Niemeyer, Hideki Muramatsu, Christian Flotho, Elliot Stieglitz and Daniel B. Lipka
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Summary:Known clinical and genetic markers have limitations in predicting disease course and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation (DNAme) patterns in JMML have correlated with outcome across multiple studies, suggesting it as a biomarker to improve patient stratification. However, standardized approaches to classify JMML based on DNAme patterns are lacking. We therefore sought to define an international consensus for DNAme subgroups in JMML and develop classification methods for clinical implementation.
Item Description:Published online first on November 2, 2020
Gesehen am 08.01.2021
Physical Description:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-20-3184

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