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Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease

In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polym...

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Main Authors: Thome, Johannes (Author) , Retz, Wolfgang (Author) , Baader, Miriam (Author) , Pesold, B. (Author) , Hu, Mei (Author) , Cowen, M. (Author) , Durany, N. (Author) , Adler, G. (Author) , Henn, Fritz A. (Author) , Rösler, Michael (Author)
Format: Article (Journal)
Language:English
Published: October 2001
In: Journal of neural transmission
Year: 2001, Volume: 108, Issue: 10, Pages: 1175-1180
ISSN:1435-1463
DOI:10.1007/s007020170007
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s007020170007
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Author Notes:J. Thome, W. Retz, M. Baader, B. Pesold, M. Hu, M. Cowen, N. Durany, G. Adler, F.A. Henn, and M. Rösler
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Summary:In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of HTR6 (267C/T) and HTR2A (−1438G/A). Although there was a tendency toward an increased number of the genotype TT of the 5-HT6 receptor polymorphism in AD patients when compared to controls (2.8% vs. 1.3%), neither this nor the 5-HT2A promoter polymorphism showed significant differences in their genotypic or allelic distribution among patients and controls. These polymorphisms probably do not represent major genetic risk factors of AD. However, further studies including other genetic variants of the serotonergic neurotransmitter system are needed in order to elucidate their role in AD.
Item Description:Gesehen am 04.11.2020
Physical Description:Online Resource
ISSN:1435-1463
DOI:10.1007/s007020170007

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