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A multitarget gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells

A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3-(1,3-dimethylxanthine-7-yl)prop-1-yn-1-yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti-metastatic, and anti-angiogenic effects. The complex also induced effects related to aneuploi...

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Main Authors: Zhang, Jing-Jing (Author) , Abu El Maaty, Mohamed A. (Author) , Hoffmeister, Henrik (Author) , Schmidt, Claudia (Author) , Münzner, Julienne K. (Author) , Schobert, Rainer (Author) , Wölfl, Stefan (Author) , Ott, Ingo (Author)
Format: Article (Journal)
Language:English
Published: 12 June 2020
In: Angewandte Chemie. International edition
Year: 2020, Volume: 59, Issue: 38, Pages: 16795-16800
ISSN:1521-3773
DOI:https://doi.org/10.1002/anie.202006212
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/anie.202006212
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202006212
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Author Notes:Jing-Jing Zhang, Mohamed A. Abu el Maaty, Henrik Hoffmeister, Claudia Schmidt, Julienne K. Muenzner, Rainer Schobert, Stefan Wölfl, Ingo Ott
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Summary:A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3-(1,3-dimethylxanthine-7-yl)prop-1-yn-1-yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti-metastatic, and anti-angiogenic effects. The complex also induced effects related to aneuploidy in HCT-116 colon carcinoma cells, which might be mainly ascribed to the dysfunction of mitochondrial bioenergetics and downregulation of glycolysis. Induction of aneuploidy beyond a critical level can provide an effective strategy to target cancer, in particular colorectal tumours with a low tolerance of aneuploidy, and could be of relevance for 1 and other metallodrugs.
Item Description:Gesehen am 10.11.2020
Physical Description:Online Resource
ISSN:1521-3773
DOI:https://doi.org/10.1002/anie.202006212

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