A multitarget gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells
A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3-(1,3-dimethylxanthine-7-yl)prop-1-yn-1-yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti-metastatic, and anti-angiogenic effects. The complex also induced effects related to aneuploi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 June 2020
|
| In: |
Angewandte Chemie. International edition
Year: 2020, Volume: 59, Issue: 38, Pages: 16795-16800 |
| ISSN: | 1521-3773 |
| DOI: | https://doi.org/10.1002/anie.202006212 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/anie.202006212 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202006212 
|
| Author Notes: | Jing-Jing Zhang, Mohamed A. Abu el Maaty, Henrik Hoffmeister, Claudia Schmidt, Julienne K. Muenzner, Rainer Schobert, Stefan Wölfl, Ingo Ott |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1738296830 | ||
| 003 | DE-627 | ||
| 005 | 20230428161338.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201110s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/anie.202006212 |2 doi | |
| 035 | |a (DE-627)1738296830 | ||
| 035 | |a (DE-599)KXP1738296830 | ||
| 035 | |a (OCoLC)1341375288 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Zhang, Jing-Jing |e VerfasserIn |0 (DE-588)1210714434 |0 (DE-627)1698678193 |4 aut | |
| 245 | 1 | 2 | |a A multitarget gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells |c Jing-Jing Zhang, Mohamed A. Abu el Maaty, Henrik Hoffmeister, Claudia Schmidt, Julienne K. Muenzner, Rainer Schobert, Stefan Wölfl, Ingo Ott |
| 264 | 1 | |c 12 June 2020 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.11.2020 | ||
| 520 | |a A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3-(1,3-dimethylxanthine-7-yl)prop-1-yn-1-yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti-metastatic, and anti-angiogenic effects. The complex also induced effects related to aneuploidy in HCT-116 colon carcinoma cells, which might be mainly ascribed to the dysfunction of mitochondrial bioenergetics and downregulation of glycolysis. Induction of aneuploidy beyond a critical level can provide an effective strategy to target cancer, in particular colorectal tumours with a low tolerance of aneuploidy, and could be of relevance for 1 and other metallodrugs. | ||
| 650 | 4 | |a aneuploidy | |
| 650 | 4 | |a antitumor agents | |
| 650 | 4 | |a gold complexes | |
| 650 | 4 | |a inorganic medicinal chemistry | |
| 650 | 4 | |a metallodrugs | |
| 700 | 1 | |a Abu El Maaty, Mohamed A. |e VerfasserIn |0 (DE-588)1125045477 |0 (DE-627)879376996 |0 (DE-576)483303607 |4 aut | |
| 700 | 1 | |a Hoffmeister, Henrik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmidt, Claudia |d 1966- |e VerfasserIn |0 (DE-588)115360581 |0 (DE-627)07719621X |0 (DE-576)28983497X |4 aut | |
| 700 | 1 | |a Münzner, Julienne K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schobert, Rainer |d 1956- |e VerfasserIn |0 (DE-588)133854124 |0 (DE-627)69188482X |0 (DE-576)300149565 |4 aut | |
| 700 | 1 | |a Wölfl, Stefan |d 1959- |e VerfasserIn |0 (DE-588)121047458 |0 (DE-627)081052618 |0 (DE-576)260692360 |4 aut | |
| 700 | 1 | |a Ott, Ingo |d 1973- |e VerfasserIn |0 (DE-588)129456683 |0 (DE-627)397663773 |0 (DE-576)297669044 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Angewandte Chemie. International edition |d Weinheim : Wiley-VCH, 1998 |g 59(2020), 38, Seite 16795-16800 |h Online-Ressource |w (DE-627)320497879 |w (DE-600)2011836-3 |w (DE-576)111552060 |x 1521-3773 |7 nnas |a A multitarget gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells |
| 773 | 1 | 8 | |g volume:59 |g year:2020 |g number:38 |g pages:16795-16800 |g extent:6 |a A multitarget gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells |
| 856 | 4 | 0 | |u https://doi.org/https://doi.org/10.1002/anie.202006212 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202006212 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201110 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 121047458 |a Wölfl, Stefan |m 121047458:Wölfl, Stefan |d 160000 |d 160100 |e 160000PW121047458 |e 160100PW121047458 |k 0/160000/ |k 1/160000/160100/ |p 7 | ||
| 998 | |g 1125045477 |a Abu El Maaty, Mohamed A. |m 1125045477:Abu El Maaty, Mohamed A. |d 160000 |d 160100 |e 160000PA1125045477 |e 160100PA1125045477 |k 0/160000/ |k 1/160000/160100/ |p 2 | ||
| 999 | |a KXP-PPN1738296830 |e 3796284841 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"multitarget gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells","title":"A multitarget gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells"}],"id":{"doi":["10.1002/anie.202006212"],"eki":["1738296830"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"6 S."}],"name":{"displayForm":["Jing-Jing Zhang, Mohamed A. Abu el Maaty, Henrik Hoffmeister, Claudia Schmidt, Julienne K. Muenzner, Rainer Schobert, Stefan Wölfl, Ingo Ott"]},"recId":"1738296830","origin":[{"dateIssuedDisp":"12 June 2020","dateIssuedKey":"2020"}],"person":[{"family":"Zhang","given":"Jing-Jing","display":"Zhang, Jing-Jing","role":"aut"},{"display":"Abu El Maaty, Mohamed A.","role":"aut","given":"Mohamed A.","family":"Abu El Maaty"},{"display":"Hoffmeister, Henrik","role":"aut","given":"Henrik","family":"Hoffmeister"},{"role":"aut","display":"Schmidt, Claudia","given":"Claudia","family":"Schmidt"},{"display":"Münzner, Julienne K.","role":"aut","given":"Julienne K.","family":"Münzner"},{"display":"Schobert, Rainer","role":"aut","given":"Rainer","family":"Schobert"},{"display":"Wölfl, Stefan","role":"aut","given":"Stefan","family":"Wölfl"},{"role":"aut","display":"Ott, Ingo","given":"Ingo","family":"Ott"}],"note":["Gesehen am 10.11.2020"],"language":["eng"],"relHost":[{"origin":[{"dateIssuedKey":"1998","dateIssuedDisp":"1998-","publisher":"Wiley-VCH","publisherPlace":"Weinheim"}],"recId":"320497879","id":{"zdb":["2011836-3"],"issn":["1521-3773"],"doi":["10.1002/(ISSN)1521-3773"],"eki":["320497879"]},"pubHistory":["37.1998 -"],"disp":"A multitarget gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cellsAngewandte Chemie. International edition","language":["eng"],"note":["Gesehen am 20.12.2022","Fortsetzung der Druck-Ausgabe"],"corporate":[{"display":"Gesellschaft Deutscher Chemiker","role":"isb"}],"titleAlt":[{"title":"Angewandte Chemie / International edition"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"year":"2020","pages":"16795-16800","issue":"38","text":"59(2020), 38, Seite 16795-16800","volume":"59","extent":"6"},"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"subtitle":"a journal of the Gesellschaft Deutscher Chemiker","title_sort":"Angewandte Chemie","title":"Angewandte Chemie","partname":"International edition"}]}]} | ||
| SRT | |a ZHANGJINGJMULTITARGE1220 | ||