ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia
Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an associati...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2005
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| In: |
Neuroscience letters
Year: 2004, Volume: 377, Issue: 1, Pages: 37-39 |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/j.neulet.2004.11.062 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neulet.2004.11.062 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0304394004014776 
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| Author Notes: | H. Kölsch, F. Jessen, N. Freymann, M. Kreis, F. Hentschel, W. Maier, R. Heun |
| Summary: | Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD. |
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| Item Description: | Available online 10 December 2004 Gesehen am 10.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/j.neulet.2004.11.062 |