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Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence: results from a prospective cohort study

Introduction Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, a biomarker of lipid peroxidation, with dementia are limited. Methods Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-caus...

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Main Authors: Trares, Kira (Author) , Gào, Xīn (Author) , Perna, Laura (Author) , Rujescu, Dan (Author) , Stocker, Hannah (Author) , Möllers, Tobias (Author) , Beyreuther, Konrad (Author) , Brenner, Hermann (Author) , Schöttker, Ben (Author)
Format: Article (Journal)
Language:English
Published: 12 April 2020
In: Alzheimer's and dementia
Year: 2020, Volume: 16, Issue: 5, Pages: 804-813
ISSN:1552-5279
DOI:https://doi.org/10.1002/alz.12081
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/alz.12081
Verlag, lizenzpflichtig, Volltext: https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.12081
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Author Notes:Kira Trares, Xīn Gào, Laura Perna, Dan Rujescu, Hannah Stocker, Tobias Möllers, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
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Summary:Introduction Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, a biomarker of lipid peroxidation, with dementia are limited. Methods Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort. Results Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF2α tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8-iso-PGF2α levels were statistically significantly associated with all-cause dementia and AD incidence. Discussion Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk.
Item Description:Im Titel ist "2α" tiefgestellt
Gesehen am 10.11.2020
Physical Description:Online Resource
ISSN:1552-5279
DOI:https://doi.org/10.1002/alz.12081

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