Segregation of effector mechanisms in a tumour-specific CD8+ t-cell clone correlates with CD30 expression
In this study we have analyzed CD30-antigen expression in three melanoma-directed cytotoxic T lymphocyte (CTL) clones with a T helper 0 (Th0)-like cytokine secretion profile (i.e. interleukin (IL)-4, IL-5, and interferon (IFN)-γ). We show that all CTL clones expressed high levels of CD30 upon contac...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 December 2001
|
| In: |
Scandinavian journal of immunology
Year: 2001, Jahrgang: 54, Heft: 3, Pages: 314-320 |
| ISSN: | 1365-3083 |
| DOI: | https://doi.org/10.1046/j.1365-3083.2001.00971.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1046/j.1365-3083.2001.00971.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-3083.2001.00971.x 
|
| Verfasserangaben: | Y. Sun, M. Song, M.J. Maeurer & D. Schadendorf |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1738321169 | ||
| 003 | DE-627 | ||
| 005 | 20220819020309.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201110s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1046/j.1365-3083.2001.00971.x |2 doi | |
| 035 | |a (DE-627)1738321169 | ||
| 035 | |a (DE-599)KXP1738321169 | ||
| 035 | |a (OCoLC)1341376270 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sun, Yuansheng |d 1963- |e VerfasserIn |0 (DE-588)122433009 |0 (DE-627)70590590X |0 (DE-576)293268029 |4 aut | |
| 245 | 1 | 0 | |a Segregation of effector mechanisms in a tumour-specific CD8+ t-cell clone correlates with CD30 expression |c Y. Sun, M. Song, M.J. Maeurer & D. Schadendorf |
| 264 | 1 | |c 23 December 2001 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.11.2020 | ||
| 520 | |a In this study we have analyzed CD30-antigen expression in three melanoma-directed cytotoxic T lymphocyte (CTL) clones with a T helper 0 (Th0)-like cytokine secretion profile (i.e. interleukin (IL)-4, IL-5, and interferon (IFN)-γ). We show that all CTL clones expressed high levels of CD30 upon contact with the autologous tumour cells. One CTL clone, termed A2 with a monoclonal feature was selected for further analyses and found its CD30 expression dependent on the presence of IL-4. Functionally, a CD30-expressing A2 CTL was capable of producing higher amounts of IFN-γ (up to 1.5-fold) and IL-4 (up to two-fold) than its CD30− counterpart. Furthermore, CD30-positive A2 CTL displayed an at least three-fold greater proliferative response to the tumour cell stimulation, contrasting with CD30− CTL. However, the antitumour cytotoxic activity of A2 CTL was not modulated by the CD30 expression. These results suggest that CD30 antigen can be inducible on a subset of tumour-directed CD8+ CTL, and that this subset of cells may have profound effector functions, such as cytokine secretion, proliferation, and cytotoxicity. | ||
| 700 | 1 | |a Song, Mingxia |d 1965- |e VerfasserIn |0 (DE-588)131798189 |0 (DE-627)514263016 |0 (DE-576)255081332 |4 aut | |
| 700 | 1 | |a Schadendorf, Dirk |d 1960- |e VerfasserIn |0 (DE-588)11142576X |0 (DE-627)499566076 |0 (DE-576)289702275 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scandinavian journal of immunology |d Oxford [u.a.] : Wiley-Blackwell, 1972 |g 54(2001), 3, Seite 314-320 |h Online-Ressource |w (DE-627)320607623 |w (DE-600)2020954-X |w (DE-576)091170265 |x 1365-3083 |7 nnas |a Segregation of effector mechanisms in a tumour-specific CD8+ t-cell clone correlates with CD30 expression |
| 773 | 1 | 8 | |g volume:54 |g year:2001 |g number:3 |g pages:314-320 |g extent:7 |a Segregation of effector mechanisms in a tumour-specific CD8+ t-cell clone correlates with CD30 expression |
| 856 | 4 | 0 | |u https://doi.org/https://doi.org/10.1046/j.1365-3083.2001.00971.x |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-3083.2001.00971.x |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201110 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 11142576X |a Schadendorf, Dirk |m 11142576X:Schadendorf, Dirk |d 50000 |e 50000PS11142576X |k 0/50000/ |p 4 |y j | ||
| 998 | |g 131798189 |a Song, Mingxia |m 131798189:Song, Mingxia |d 50000 |e 50000PS131798189 |k 0/50000/ |p 2 | ||
| 999 | |a KXP-PPN1738321169 |e 3796373321 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"disp":"Segregation of effector mechanisms in a tumour-specific CD8+ t-cell clone correlates with CD30 expressionScandinavian journal of immunology","note":["Gesehen am 11.04.2022"],"id":{"eki":["320607623"],"doi":["10.1111/(ISSN)1365-3083"],"zdb":["2020954-X"],"issn":["1365-3083"]},"title":[{"subtitle":"the official journal of the Scandinavian Society for Immunology","title":"Scandinavian journal of immunology","title_sort":"Scandinavian journal of immunology"}],"part":{"year":"2001","extent":"7","pages":"314-320","text":"54(2001), 3, Seite 314-320","volume":"54","issue":"3"},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"publisher":"Wiley-Blackwell ; Blackwell Science ; Blackwell","dateIssuedKey":"1972","publisherPlace":"Oxford [u.a.] ; Oxford ; Oxford [u.a.]","dateIssuedDisp":"1972-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1972 -"],"recId":"320607623"}],"physDesc":[{"extent":"7 S."}],"person":[{"family":"Sun","roleDisplay":"VerfasserIn","display":"Sun, Yuansheng","role":"aut","given":"Yuansheng"},{"role":"aut","display":"Song, Mingxia","given":"Mingxia","family":"Song","roleDisplay":"VerfasserIn"},{"given":"Dirk","role":"aut","display":"Schadendorf, Dirk","roleDisplay":"VerfasserIn","family":"Schadendorf"}],"name":{"displayForm":["Y. Sun, M. Song, M.J. Maeurer & D. Schadendorf"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"23 December 2001","dateIssuedKey":"2001"}],"language":["eng"],"note":["Gesehen am 10.11.2020"],"recId":"1738321169","id":{"eki":["1738321169"],"doi":["10.1046/j.1365-3083.2001.00971.x"]},"title":[{"title":"Segregation of effector mechanisms in a tumour-specific CD8+ t-cell clone correlates with CD30 expression","title_sort":"Segregation of effector mechanisms in a tumour-specific CD8+ t-cell clone correlates with CD30 expression"}]} | ||
| SRT | |a SUNYUANSHESEGREGATIO2320 | ||