Structural features of coronavirus SARS-CoV-2 spike protein: targets for vaccination
Various human pathogenic viruses employ envelope glycoproteins for host cell receptor recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of betacoronavirus SARS-CoV-2 is a homotrimeric class I fusion protein that exists in a metastable conformation for cleavage by h...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
6 July 2020
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| In: |
Life sciences
Year: 2020, Volume: 257 |
| ISSN: | 1879-0631 |
| DOI: | 10.1016/j.lfs.2020.118056 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.lfs.2020.118056 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0024320520308079 
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| Author Notes: | Ariane Sternberg, Cord Naujokat |
| Summary: | Various human pathogenic viruses employ envelope glycoproteins for host cell receptor recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of betacoronavirus SARS-CoV-2 is a homotrimeric class I fusion protein that exists in a metastable conformation for cleavage by host cell proteases furin and TMPRSS2, thereby undergoing substantial structural rearrangement for ACE2 host cell receptor binding and subsequent viral entry by membrane fusion. The S protein is densely decorated with N-linked glycans protruding from the trimer surface that affect S protein folding, processing by host cell proteases and the elicitation of humoral immune response. Deep insight into the sophisticated structure of SARS-CoV-2 S protein may provide a blueprint for vaccination strategies, as reviewed herein. |
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| Item Description: | Gesehen am 11.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0631 |
| DOI: | 10.1016/j.lfs.2020.118056 |