Dance with the devil: stress granules and signaling in antiviral responses
Cells have evolved highly specialized sentinels that detect viral infection and elicit an antiviral response. Among these, the stress-sensing protein kinase R, which is activated by double-stranded RNA, mediates suppression of the host translation machinery as a strategy to limit viral replication....
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 September 2020
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| In: |
Viruses
Year: 2020, Volume: 12, Issue: 9 |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v12090984 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/v12090984 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1999-4915/12/9/984 
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| Author Notes: | Nina Eiermann, Katharina Haneke, Zhaozhi Sun, Georg Stoecklin and Alessia Ruggieri |
| Summary: | Cells have evolved highly specialized sentinels that detect viral infection and elicit an antiviral response. Among these, the stress-sensing protein kinase R, which is activated by double-stranded RNA, mediates suppression of the host translation machinery as a strategy to limit viral replication. Non-translating mRNAs rapidly condensate by phase separation into cytosolic stress granules, together with numerous RNA-binding proteins and components of signal transduction pathways. Growing evidence suggests that the integrated stress response, and stress granules in particular, contribute to antiviral defense. This review summarizes the current understanding of how stress and innate immune signaling act in concert to mount an effective response against virus infection, with a particular focus on the potential role of stress granules in the coordination of antiviral signaling cascades. |
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| Item Description: | Gesehen am 12.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v12090984 |