Cover Image

Acute stress decreases serotonin transporter mRNA in the raphe pontis but not in other raphe nuclei of the rat

In addition to elevated corticosterone levels, stress produces structural changes and neuronal damage especially in the hippocampus. In this line it has been shown, that in rats single or repeated immobilisation markedly reduces brain-derived neurotrophic factor (BDNF) mRNA levels in the hippocampal...

Full description

Saved in:
Bibliographic Details
Main Authors: Vollmayr, Barbara (Author) , Keck, S (Author) , Henn, Fritz A. (Author) , Schloss, Patrick (Author)
Format: Article (Journal)
Language:English
Published: 7 August 2000
In: Neuroscience letters
Year: 2000, Volume: 290, Issue: 2, Pages: 109-112
ISSN:1872-7972
DOI:10.1016/S0304-3940(00)01346-X
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0304-3940(00)01346-X
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S030439400001346X
Get full text
Author Notes:B. Vollmayr, S. Keck, F.A Henn, P. Schloss
Description
Summary:In addition to elevated corticosterone levels, stress produces structural changes and neuronal damage especially in the hippocampus. In this line it has been shown, that in rats single or repeated immobilisation markedly reduces brain-derived neurotrophic factor (BDNF) mRNA levels in the hippocampal formation. Since this neurotrophin also controls the efficacy of serotonergic neurotransmission, the aim of the current study was to investigate the effect of acute immobilization stress on the expression of serotonin transporter (SERT) mRNA in the raphe nuclei as a parameter of serotonergic innervation. We have examined the expression of SERT mRNA and of BDNF mRNA in rats upon acute immobilisation by quantitative in situ hybridisation with a 35S-labelled oligonucleotide probe. Elevated corticosterone levels in stressed animals confirmed as internal controls the effect of stress under our conditions. Acute stress led to a significant decrease of BDNF mRNA in the hippocampus and of SERT mRNA in the raphe pontis, but not in other raphe nuclei investigated. These data provide evidence for fast interactions between neurotrophins, corticosterone and serotonergic neurotransmission under stress conditions.
Item Description:Gesehen am 12.11.2020
Physical Description:Online Resource
ISSN:1872-7972
DOI:10.1016/S0304-3940(00)01346-X

Similar Items