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Impact of ambient temperature on inflammation-induced encephalopathy in endotoxemic mice: role of phosphoinositide 3-kinase gamma

Sepsis-associated encephalopathy (SAE) is an early and frequent event of infection-induced systemic inflammatory response syndrome. Phosphoinositide 3-kinase γ (PI3Kγ) is linked to neuroinflammation and inflammation-related microglial activity. In homeotherms, variations in ambient temperature (Ta)...

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Main Authors: Lang, Guang-Ping (Author) , Ndongson-Dongmo, Bernadin (Author) , Lajqi, Trim (Author) , Brodhun, Michael (Author) , Han, Yingying (Author) , Wetzker, Reinhard (Author) , Frasch, Martin G. (Author) , Bauer, Reinhard (Author)
Format: Article (Journal)
Language:English
Published: 07 October 2020
In: Journal of neuroinflammation
Year: 2020, Volume: 17
ISSN:1742-2094
DOI:10.1186/s12974-020-01954-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12974-020-01954-7
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Author Notes:Guang-Ping Lang, Bernadin Ndongson-Dongmo, Trim Lajqi, Michael Brodhun, Yingying Han, Reinhard Wetzker, Martin G. Frasch and Reinhard Bauer
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Summary:Sepsis-associated encephalopathy (SAE) is an early and frequent event of infection-induced systemic inflammatory response syndrome. Phosphoinositide 3-kinase γ (PI3Kγ) is linked to neuroinflammation and inflammation-related microglial activity. In homeotherms, variations in ambient temperature (Ta) outside the thermoneutral zone lead to thermoregulatory responses, mainly driven by a gradually increasing sympathetic activity, and may affect disease severity. We hypothesized that thermoregulatory response to hypothermia (reduced Ta) aggravates SAE in PI3Kγ-dependent manner.
Item Description:Gesehen am 12.11.2020
Physical Description:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-020-01954-7

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