Small physical cross-linker facilitates hyaluronan hydrogels
In this study, we demonstrate that small charged molecules (NH4+, GluA+, dHA+) can form physical cross-links between hyaluronan chains, facilitating polymerization reactions between synthetically introduced thiol groups (HA-DTPH). These hybrid hydrogels can be obtained under physiological conditions...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 September 2020
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| In: |
Molecules
Year: 2020, Volume: 25, Issue: 18 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25184166 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/molecules25184166 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1420-3049/25/18/4166 
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| Author Notes: | Saliha Erikci, Patricia Mundinger and Heike Boehm |
| Summary: | In this study, we demonstrate that small charged molecules (NH4+, GluA+, dHA+) can form physical cross-links between hyaluronan chains, facilitating polymerization reactions between synthetically introduced thiol groups (HA-DTPH). These hybrid hydrogels can be obtained under physiological conditions ideally suited for 3D cell culture systems. The type and concentration of a physical crosslinker can be adjusted to precisely tune mechanical properties as well as degradability of the desired hydrogel system. We analyze the influence of hydrogen bond formation, concentration and additional ionic interactions on the polymerization reaction of HA-DTPH hydrogels and characterize the resulting hydrogels in regard to mechanical and biocompatibility aspects. |
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| Item Description: | Gesehen am 16.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25184166 |