The role of the proteasome activator PA28 in MHC class I antigen processing
The proteasome system is the major source for the generation of viral antigens and tumor antigens presented by major histocompatibility complex class I (MHC class I) molecules. A specific feature of the proteasomal antigen processing machinery is that five of its components are inducible by IFN-γ. T...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 August 2002
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| In: |
Molecular immunology
Year: 2002, Volume: 39, Issue: 3, Pages: 165-169 |
| ISSN: | 1872-9142 |
| DOI: | 10.1016/S0161-5890(02)00099-8 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0161-5890(02)00099-8 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0161589002000998 
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| Author Notes: | Alice Sijts, Yuancheng Sun, Katarina Janek, Sylvie Kral, Annette Paschen, Dirk Schadendorf, Peter-M. Kloetzel |
| Summary: | The proteasome system is the major source for the generation of viral antigens and tumor antigens presented by major histocompatibility complex class I (MHC class I) molecules. A specific feature of the proteasomal antigen processing machinery is that five of its components are inducible by IFN-γ. Two of these are the α and β subunits of the proteasome activator PA28. Our results show that PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen. |
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| Item Description: | Gesehen am 17.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1872-9142 |
| DOI: | 10.1016/S0161-5890(02)00099-8 |