Cover Image

Genomic knockout of endogenous canine P-Glycoprotein in wild-type, human P-Glycoprotein and human BCRP transfected MDCKII cell lines by Zinc Finger Nucleases

To investigate whether it is possible to specifically suppress the expression and function of endogenous canine P-glycoprotein (cPgp) in Madin-Darby canine kidney type II cells (MDCKII) transfected with hPGP and breast cancer resistance protein (hBCRP) by zinc finger nuclease (ZFN) producing sequenc...

Full description

Saved in:
Bibliographic Details
Main Authors: Gartzke, Dominik (Author) , Delzer, Jürgen (Author) , Laplanche, Loic (Author) , Uchida, Yasuo (Author) , Hoshi, Yutaro (Author) , Tachikawa, Masanori (Author) , Terasaki, Tetsuya (Author) , Sydor, Jens R. (Author) , Fricker, Gert (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Pharmaceutical research
Year: 2014, Volume: 32, Issue: 6, Pages: 2060-2071
ISSN:1573-904X
DOI:10.1007/s11095-014-1599-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11095-014-1599-5
Get full text
Author Notes:Dominik Gartzke, Jürgen Delzer, Loic Laplanche, Yasuo Uchida, Yutaro Hoshi, Masanori Tachikawa, Tetsuya Terasaki, Jens Sydor, Gert Fricker
Description
Summary:To investigate whether it is possible to specifically suppress the expression and function of endogenous canine P-glycoprotein (cPgp) in Madin-Darby canine kidney type II cells (MDCKII) transfected with hPGP and breast cancer resistance protein (hBCRP) by zinc finger nuclease (ZFN) producing sequence specific DNA double strand breaks.
Item Description:Published: 19 December 2014
Gesehen am 24.11.2020
Physical Description:Online Resource
ISSN:1573-904X
DOI:10.1007/s11095-014-1599-5

Similar Items